ace-3 Carboxylic ester hydrolase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ace-3
Official Full Name: Carboxylic ester hydrolase
Primary source: WormBase:WBGene00000037
Locus tag: CELE_Y48B6A.8
See related: AllianceGenome:WB:WBGene00000037
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables acetylcholinesterase activity and protein homodimerization activity. Involved in several processes, including acetylcholine catabolic process; hatching; and regulation of backward locomotion. Predicted to be located in synaptic cleft. Predicted to be active in extracellular space and plasma membrane. Is expressed in body wall musculature; neurons; pharyngeal muscle cell; and vulva. Human ortholog(s) of this gene implicated in several diseases, including coronary artery disease (multiple); diabetes mellitus (multiple); drug dependence (multiple); myasthenia gravis; and subacute delirium. Orthologous to human ACHE (acetylcholinesterase (Yt blood group)) and BCHE (butyrylcholinesterase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ace-3 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 8

Sequence:: Chromosome: II; NC_003280.10 (14205635..14210214)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ACE-1 is an amphiphilic tetramer associated with a hydrophobic non-catalytic subunit, analogous to vertebrate T enzymes, whereas ACE-2 and ACE-3 are glycosylphosphatidylinositol-linked amphiphilic dimers
Title: Nematode acetylcholinesterases are encoded by multiple genes and perform non-overlapping functions.

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General gene information

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Markers

Y119D3_455.a (e-PCR)
- UniSTS:323874

Y119D3_455.d (e-PCR)
- UniSTS:323490

Y48B6A.8 (e-PCR)
- UniSTS:321744

STS2-216 (e-PCR)
- UniSTS:241892

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables acetylcholinesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetylcholinesterase activity	IDA Inferred from Direct Assay more info	PubMed
enables acetylcholinesterase activity	IEA Inferred from Electronic Annotation more info
enables carboxylic ester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables cholinesterase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in acetylcholine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in acetylcholine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in acetylcholine catabolic process in synaptic cleft	IC Inferred by Curator more info	PubMed
involved_in choline metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in hatching	IGI Inferred from Genetic Interaction more info	PubMed
involved_in multicellular organismal movement	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nematode larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of backward locomotion	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptic cleft	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Carboxylic ester hydrolase

NP_496963.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

14205635..14210214

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_064562.6 → NP_496963.1 Carboxylic ester hydrolase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496963.1

Status: REVIEWED

UniProtKB/TrEMBL

O61459, Q9U295

Conserved Domains (2) summary

COG0657
Location:123 → 234

Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

pfam00135
Location:28 → 564

COesterase; Carboxylesterase family