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ctl-3 Catalase [ Caenorhabditis elegans ]

Gene ID: 175086, updated on 2-Nov-2024

Summary

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Official Symbol
ctl-3
Official Full Name
Catalase
Primary source
WormBase:WBGene00013220
Locus tag
CELE_Y54G11A.13
See related
AllianceGenome:WB:WBGene00013220
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable catalase activity and heme binding activity. Predicted to be involved in hydrogen peroxide catabolic process and response to hydrogen peroxide. Predicted to be active in mitochondrion and peroxisome. Is expressed in neurons and pharyngeal muscle cell. Human ortholog(s) of this gene implicated in several diseases, including acatalasia; eye disease (multiple); lung disease (multiple); osteonecrosis; and pseudoxanthoma elasticum. Orthologous to human CAT (catalase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ctl-3 in Genome Data Viewer
Location:
chromosome: II
Exon count:
5
Sequence:
Chromosome: II; NC_003280.10 (14307798..14310779, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Tetratricopeptide repeat protein 38 Neighboring gene Peroxisomal catalase 1 Neighboring gene Catalase-2 Neighboring gene ncRNA Neighboring gene Transcriptional regulator;YTH domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Lack of peroxisomal catalase causes a progeric phenotype in Caenorhabditis elegans. Petriv OI, et al. J Biol Chem, 2004 May 7. PMID 14996832
  2. Increased levels of hydrogen peroxide induce a HIF-1-dependent modification of lipid metabolism in AMPK compromised C. elegans dauer larvae. Xie M, et al. Cell Metab, 2012 Sep 5. PMID 22921415
  3. Ecotoxicity of Caenorhabditis elegans following a step and repeated chronic exposure to tetrabromobisphenol A. Liu F, et al. Ecotoxicol Environ Saf, 2019 Mar. PMID 30453175
  4. Combined exposure to methylmercury and manganese during L1 larval stage causes motor dysfunction, cholinergic and monoaminergic up-regulation and oxidative stress in L4 Caenorhabditis elegans. Schetinger MRC, et al. Toxicology, 2019 Jan 1. PMID 30336192, Free PMC Article
  5. Antioxidant enzymes and their role in phoxim and carbaryl stress in Caenorhabditis elegans. Han Y, et al. Pestic Biochem Physiol, 2017 May. PMID 28456303

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables catalase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables catalase activity IEA
Inferred from Electronic Annotation
more info
  
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peroxidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
  
involved_in hydrogen peroxide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hydrogen peroxide catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in response to hydrogen peroxide IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Catalase
NP_001293540.1
  • Confirmed by transcript evidence
NP_741058.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    14307798..14310779 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171051.4 → NP_741058.1  Catalase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741058.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MYL7
    Conserved Domains (2) summary
    cd08156
    Location:79 → 507
    catalase_clade_3; Clade 3 of the heme-binding enzyme catalase
    COG0753
    Location:38 → 507
    KatE; Catalase [Inorganic ion transport and metabolism]

  2. NM_001306611.3 → NP_001293540.1  Catalase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293540.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PE16
    Conserved Domains (2) summary
    cd08156
    Location:60 → 488
    catalase_clade_3; Clade 3 of the heme-binding enzyme catalase
    COG0753
    Location:19 → 488
    KatE; Catalase [Inorganic ion transport and metabolism]
Nucleotide Protein
Heading Accession and Version

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