agl-1 Glycogen debranching enzyme [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: agl-1
Official Full Name: Glycogen debranching enzyme
Primary source: WormBase:WBGene00011050
Locus tag: CELE_R06A4.8
See related: AllianceGenome:WB:WBGene00011050
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable 4-alpha-glucanotransferase activity and amylo-alpha-1,6-glucosidase activity. Predicted to be involved in glycogen catabolic process. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in glycogen storage disease III. Orthologous to human AGL (amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See agl-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 11

Sequence:: Chromosome: II; NC_003280.10 (14350713..14358113, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Agl1 deficient animals have reduced lifespan and dramatic increase of glucosylated oligomannose glycans.
Title: Deficiency of α-glucosidase I alters glycoprotein glycosylation and lifespan in Caenorhabditis elegans.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R06A4.8 (e-PCR)
- UniSTS:321614

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 4-alpha-glucanotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 4-alpha-glucanotransferase activity	IEA Inferred from Electronic Annotation more info
enables amylo-alpha-1,6-glucosidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables amylo-alpha-1,6-glucosidase activity	IEA Inferred from Electronic Annotation more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on glycosyl bonds	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycogen biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in glycogen catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycogen catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Glycogen debranching enzyme

NP_496984.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

14350713..14358113 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_064583.6 → NP_496984.1 Glycogen debranching enzyme [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496984.1

Status: REVIEWED

UniProtKB/TrEMBL

O62334

Conserved Domains (5) summary

cd11327
Location:93 → 574

AmyAc_Glg_debranch_2; Alpha amylase catalytic domain found in glycogen debranching enzymes

TIGR01531
Location:22 → 1462

glyc_debranch; glycogen debranching enzymye

pfam06202
Location:998 → 1457

GDE_C; Amylo-alpha-1,6-glucosidase

pfam14699
Location:31 → 105

hGDE_N; N-terminal domain from the human glycogen debranching enzyme

pfam14702
Location:682 → 931

hGDE_central; central domain of human glycogen debranching enzyme