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pfs-2 pre-mRNA 3' end processing protein pfs-2 [ Caenorhabditis elegans ]

Gene ID: 175092, updated on 2-Nov-2024

Summary

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Official Symbol
pfs-2
Official Full Name
pre-mRNA 3' end processing protein pfs-2
Primary source
WormBase:WBGene00011051
Locus tag
CELE_R06A4.9
See related
AllianceGenome:WB:WBGene00011051
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in mRNA 3'-end processing. Located in nuclear speck. Orthologous to human WDR33 (WD repeat domain 33). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pfs-2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
7
Sequence:
Chromosome: II; NC_003280.10 (14358366..14361684)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Protein lin-7 homolog Neighboring gene L51_S25_CI-B8 domain-containing protein Neighboring gene Transcription elongation factor 1 homolog Neighboring gene Glycogen debranching enzyme Neighboring gene SPK domain-containing protein Neighboring gene Importin N-terminal domain-containing protein Neighboring gene AcetylCholine Receptor

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The C. elegans 3' UTRome v2 resource for studying mRNA cleavage and polyadenylation, 3'-UTR biology, and miRNA targeting. Steber HS, et al. Genome Res, 2019 Dec. PMID 31744903, Free PMC Article
  2. Nuclear pre-mRNA 3'-end processing regulates synapse and axon development in C. elegans. Van Epps H, et al. Development, 2010 Jul. PMID 20530551, Free PMC Article
  3. Systematic transcriptome analysis associated with physiological and chronological aging in Caenorhabditis elegans. Ham S, et al. Genome Res, 2022 Nov-Dec. PMID 36351769, Free PMC Article
  4. Casein Kinase 1δ Stabilizes Mature Axons by Inhibiting Transcription Termination of Ankyrin. LaBella ML, et al. Dev Cell, 2020 Jan 6. PMID 31910362, Free PMC Article
  5. ITSN-1 controls vesicle recycling at the neuromuscular junction and functions in parallel with DAB-1. Wang W, et al. Traffic, 2008 May. PMID 18298590, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in mRNA 3'-end processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of mRNA cleavage and polyadenylation specificity factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
pre-mRNA 3' end processing protein pfs-2
NP_001368351.1
  • Confirmed by transcript evidence
NP_001379014.1
  • Confirmed by transcript evidence
NP_001380152.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    14358366..14361684
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001393231.1 → NP_001380152.1  pre-mRNA 3' end processing protein pfs-2 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A5S9MNP8, U4PCM1, U4PN22
    Conserved Domains (2) summary
    cd00200
    Location:135 → 417
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:136 → 173
    7WD40; WD40 repeat [structural motif]

  2. NM_001393232.1 → NP_001379014.1  pre-mRNA 3' end processing protein pfs-2 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (2) summary
    smart00320
    Location:135 → 161
    WD40; WD40 repeats
    sd00039
    Location:137 → 172
    7WD40; WD40 repeat [structural motif]

  3. NM_001381653.1 → NP_001368351.1  pre-mRNA 3' end processing protein pfs-2 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (2) summary
    cd00200
    Location:5 → 212
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:16 → 52
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
U4PCM1.2

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