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imb-2 Importin N-terminal domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 175094, updated on 2-Nov-2024

Summary

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Official Symbol
imb-2
Official Full Name
Importin N-terminal domain-containing protein
Primary source
WormBase:WBGene00002076
Locus tag
CELE_R06A4.4
See related
AllianceGenome:WB:WBGene00002076
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in protein import into nucleus. Predicted to be active in cytoplasm and nucleus. Is expressed in AWC-ON; AWCL; and AWCR. Human ortholog(s) of this gene implicated in intellectual developmental disorder with hypotonia, impaired speech, and dysmorphic facies. Orthologous to several human genes including TNPO2 (transportin 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See imb-2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
7
Sequence:
Chromosome: II; NC_003280.10 (14365701..14373901)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene pre-mRNA 3' end processing protein pfs-2 Neighboring gene SPK domain-containing protein Neighboring gene AcetylCholine Receptor Neighboring gene SKN-1 Dependent Zygotic transcript Neighboring gene Histone-lysine N-methyltransferase mes-2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sevoflurane Preconditioning Increases Stress Resistance via IMB-2/DAF-16 in Caenorhabditis Elegans. Cao Y, et al. Dose Response, 2022 Jan-Mar. PMID 35360453, Free PMC Article
  2. A universal transportin protein drives stochastic choice of olfactory neurons via specific nuclear import of a sox-2-activating factor. Alqadah A, et al. Proc Natl Acad Sci U S A, 2019 Dec 10. PMID 31767767, Free PMC Article
  3. Redox-dependent control of FOXO/DAF-16 by transportin-1. Putker M, et al. Mol Cell, 2013 Feb 21. PMID 23333309
  4. Activation of DAF-16/FOXO by reactive oxygen species contributes to longevity in long-lived mitochondrial mutants in Caenorhabditis elegans. Senchuk MM, et al. PLoS Genet, 2018 Mar. PMID 29522556, Free PMC Article
  5. Evolutionary and transcriptional analysis of karyopherin beta superfamily proteins. Quan Y, et al. Mol Cell Proteomics, 2008 Jul. PMID 18353765, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables nuclear import signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into nucleus IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Importin N-terminal domain-containing protein
NP_001309574.1
  • Confirmed by transcript evidence
NP_496987.1
  • Confirmed by transcript evidence
NP_496988.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    14365701..14373901
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001322761.3 → NP_001309574.1  Importin N-terminal domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MBF9
    Conserved Domains (2) summary
    COG5215
    Location:15 → 764
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    sd00044
    Location:388 → 416
    HEAT; HEAT repeat [structural motif]

  2. NM_064587.5 → NP_496988.1  Importin N-terminal domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496988.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O62333

  3. NM_064586.4 → NP_496987.1  Importin N-terminal domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496987.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O62332
    Conserved Domains (2) summary
    COG5215
    Location:15 → 758
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    sd00044
    Location:388 → 416
    HEAT; HEAT repeat [structural motif]
Nucleotide Protein
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