plx-2 Plexin-2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: plx-2
Official Full Name: Plexin-2
Primary source: WormBase:WBGene00004048
Locus tag: CELE_K04B12.1
See related: AllianceGenome:WB:WBGene00004048
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables semaphorin receptor activity. Involved in several processes, including axonal fasciculation; nematode larval development; and nematode male tail tip morphogenesis. Located in cell leading edge and cell surface. Is expressed in several structures, including P10; P9/10L; P9/10R; neuroblasts; and ray structural cell. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See plx-2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 15

Sequence:: Chromosome: II; NC_003280.10 (14417855..14424891, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PLX-2 plays role in the cell movements for ventral enclosure in C. elegans
Title: Semaphorin and Eph receptor signaling guide a series of cell movements for ventral enclosure in C. elegans.
EFN-4 and PLX-2 are coexpressed in the late embryonic epidermis where they play redundant roles in MAB-20-dependent cell sorting.
Title: The PLEXIN PLX-2 and the ephrin EFN-4 have distinct roles in MAB-20/Semaphorin 2A signaling in Caenorhabditis elegans morphogenesis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K04B12.1 (e-PCR)
- UniSTS:311400

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables semaphorin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables semaphorin receptor activity	IEA Inferred from Electronic Annotation more info
enables semaphorin receptor activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in axonal fasciculation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in embryo development ending in birth or egg hatching	IGI Inferred from Genetic Interaction more info	PubMed
involved_in motor neuron axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in nematode larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nematode male tail tip morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell shape	IBA Inferred from Biological aspect of Ancestor more info
involved_in semaphorin-plexin signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in semaphorin-plexin signaling pathway	IC Inferred by Curator more info	PubMed
involved_in semaphorin-plexin signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in sensory neuron axon guidance	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell leading edge	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of semaphorin receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Plexin-2

NP_001364609.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

14417855..14424891 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001377900.1 → NP_001364609.1 Plexin-2 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

O45657, Q6BCZ2

Conserved Domains (8) summary

smart00423
Location:447 → 488

PSI; domain found in Plexins, Semaphorins and Integrins

cd01179
Location:841 → 925

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:750 → 839

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:577 → 615

PSI; Plexin repeat

pfam08337
Location:1213 → 1744

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:496 → 546

TIG_plexin; TIG domain

cl15674
Location:928 → 1017

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

cl15693
Location:38 → 415

Sema; The Sema domain, a protein interacting module, of semaphorins and plexins