U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

dhs-8 SDR family NAD(P)-dependent oxidoreductase [ Caenorhabditis elegans ]

Gene ID: 175108, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
dhs-8
Official Full Name
SDR family NAD(P)-dependent oxidoreductase
Primary source
WormBase:WBGene00000972
Locus tag
CELE_K10H10.3
See related
AllianceGenome:WB:WBGene00000972
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable oxidoreductase activity. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 12; developmental and epileptic encephalopathy 28; esophagus squamous cell carcinoma; and squamous cell carcinoma. Orthologous to human WWOX (WW domain containing oxidoreductase). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See dhs-8 in Genome Data Viewer
Location:
chromosome: II
Exon count:
6
Sequence:
Chromosome: II; NC_003280.10 (14498026..14499755)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene Bifunctional L-3-cyanoalanine synthase/cysteine synthase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene AT rich interactive domain 1B (SWI1-like);Secreted protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
  2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
SDR family NAD(P)-dependent oxidoreductase
NP_001022250.1
  • Partially confirmed by transcript evidence
NP_001293543.1
  • Confirmed by transcript evidence
NP_001368222.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    14498026..14499755
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027079.3 → NP_001022250.1  SDR family NAD(P)-dependent oxidoreductase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022250.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O45680
    Conserved Domains (2) summary
    PRK06196
    Location:68 → 362
    PRK06196; oxidoreductase; Provisional
    cl21454
    Location:85 → 362
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. NM_001381658.1 → NP_001368222.1  SDR family NAD(P)-dependent oxidoreductase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PLQ0
    Conserved Domains (1) summary
    cl21454
    Location:27 → 304
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  3. NM_001306614.3 → NP_001293543.1  SDR family NAD(P)-dependent oxidoreductase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293543.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PB98
    Conserved Domains (1) summary
    cl21454
    Location:1 → 248
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RNA

  1. NR_002361.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools