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pot-2 Protection of telomeres homolog 2 [ Caenorhabditis elegans ]

Gene ID: 175110, updated on 2-Nov-2024

Summary

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Official Symbol
pot-2
Official Full Name
Protection of telomeres homolog 2
Primary source
WormBase:WBGene00010195
Locus tag
CELE_F57C2.3
See related
AllianceGenome:WB:WBGene00010195
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables G-rich strand telomeric DNA binding activity. Involved in negative regulation of telomere maintenance via telomere lengthening and telomere maintenance. Located in chromosome, telomeric region. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pot-2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
3
Sequence:
Chromosome: II; NC_003280.10 (14524173..14525108)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene BTB domain-containing protein Neighboring gene BTB domain-containing protein Neighboring gene Toxin Neighboring gene Strictosidine synthase conserved region domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Genetic Basis of Natural Variation in Caenorhabditis elegans Telomere Length. Cook DE, et al. Genetics, 2016 Sep. PMID 27449056, Free PMC Article
  2. Telomeric double-strand DNA-binding proteins DTN-1 and DTN-2 ensure germline immortality in Caenorhabditis elegans. Yamamoto I, et al. Elife, 2021 Jan 21. PMID 33476260, Free PMC Article
  3. Caenorhabditis elegans POT-2 telomere protein represses a mode of alternative lengthening of telomeres with normal telomere lengths. Cheng C, et al. Proc Natl Acad Sci U S A, 2012 May 15. PMID 22547822, Free PMC Article
  4. Caenorhabditis elegans POT-1 and POT-2 repress telomere maintenance pathways. Shtessel L, et al. G3 (Bethesda), 2013 Feb. PMID 23390606, Free PMC Article
  5. TERRA expression is regulated by the telomere-binding proteins POT-1 and POT-2 in Caenorhabditis elegans. Manzato C, et al. Nucleic Acids Res, 2023 Oct 27. PMID 37713629, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TERRA expression is regulated by the telomere-binding proteins POT-1 and POT-2 in Caenorhabditis elegans.
    Title: TERRA expression is regulated by the telomere-binding proteins POT-1 and POT-2 in Caenorhabditis elegans.
  2. POT-2, single-stranded telomere-binding protein, negatively regulate telomerase- mediated telomere repeat addition.
    Title: Caenorhabditis elegans POT-1 and POT-2 repress telomere maintenance pathways.
  3. Deficiency for the POT-2 telomere binding protein promoted the alternative lengthening of telomeres pathway in telomerase mutants.
    Title: Caenorhabditis elegans POT-2 telomere protein represses a mode of alternative lengthening of telomeres with normal telomere lengths.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables G-rich strand telomeric DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables single-stranded telomeric DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded telomeric DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of telomere maintenance via telomere lengthening IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, telomeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Protection of telomeres homolog 2
NP_497017.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    14524173..14525108
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064616.5 → NP_497017.1  Protection of telomeres homolog 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497017.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O45595
    Conserved Domains (1) summary
    pfam16686
    Location:19 → 174
    POT1PC; ssDNA-binding domain of telomere protection protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O45595.1

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