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osta-3 Organic solute transporter alpha-like protein 3 [ Caenorhabditis elegans ]

Gene ID: 175140, updated on 2-Nov-2024

Summary

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Official Symbol
osta-3
Official Full Name
Organic solute transporter alpha-like protein 3
Primary source
WormBase:WBGene00012182
Locus tag
CELE_W01D2.5
See related
AllianceGenome:WB:WBGene00012182
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable transmembrane transporter activity. Predicted to be located in plasma membrane. Predicted to be active in membrane. Is expressed in neurons. Human ortholog(s) of this gene implicated in progressive familial intrahepatic cholestasis. Orthologous to human SLC51A (solute carrier family 51 member A). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See osta-3 in Genome Data Viewer
Location:
chromosome: II
Exon count:
6
Sequence:
Chromosome: II; NC_003280.10 (14813026..14814889)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class T Neighboring gene 9.7 kDa protein Neighboring gene Ribosomal protein L37 Neighboring gene Nuclear hormone receptor family member nhr-61;Nuclear receptor Neighboring gene Cadherin domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The C. elegans regulatory factor X (RFX) DAF-19M module: A shift from general ciliogenesis to cell-specific ciliary and behavioral specialization. Ahn S, et al. Cell Rep, 2022 Apr 12. PMID 35417689
  2. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article
  3. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Organic solute transporter alpha-like protein 3
NP_001293580.1
  • Confirmed by transcript evidence
NP_497071.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    14813026..14814889
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064670.6 → NP_497071.1  Organic solute transporter alpha-like protein 3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497071.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XU63
    Conserved Domains (1) summary
    pfam03619
    Location:50 → 311
    Solute_trans_a; Organic solute transporter Ostalpha

  2. NM_001306651.3 → NP_001293580.1  Organic solute transporter alpha-like protein 3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293580.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PEW3
    Conserved Domains (1) summary
    pfam03619
    Location:1 → 209
    Solute_trans_a; Organic solute transporter Ostalpha
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XU63.1

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