ubc-20 E2 ubiquitin-conjugating enzyme [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ubc-20
Official Full Name: E2 ubiquitin-conjugating enzyme
Primary source: WormBase:WBGene00006715
Locus tag: CELE_F40G9.3
See related: AllianceGenome:WB:WBGene00006715
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in protein polyubiquitination. Predicted to be active in nucleus. Is expressed in several structures, including anal depressor muscle; intestine; nervous system; pharynx; and reproductive system. Orthologous to human UBE2K (ubiquitin conjugating enzyme E2 K). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ubc-20 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 5

Sequence:: Chromosome: III; NC_003281.10 (188838..190883)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS3-101 (e-PCR)
- UniSTS:241938

F40G9.11 (e-PCR)
- UniSTS:317715

F40G9.3 (e-PCR)
- UniSTS:319330

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin conjugating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin conjugating enzyme activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein modification by small protein conjugation	IEA Inferred from Electronic Annotation more info
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: E2 ubiquitin-conjugating enzyme

NP_497174.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

188838..190883

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_064773.6 → NP_497174.1 E2 ubiquitin-conjugating enzyme [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497174.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9TZ69

Conserved Domains (2) summary

cd14313
Location:163 → 198

UBA_II_E2_UBE2K_like; UBA domain found in vertebrate ubiquitin-conjugating enzyme E2 K (UBE2K), Drosophila melanogaster ubiquitin-conjugating enzyme E2-22 kDa (UbcD4) and similar proteins

pfam00179
Location:8 → 149

UQ_con; Ubiquitin-conjugating enzyme