U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

stim-1 Stromal interaction molecule 1 [ Caenorhabditis elegans ]

Gene ID: 175201, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
stim-1
Official Full Name
Stromal interaction molecule 1
Primary source
WormBase:WBGene00021910
Locus tag
CELE_Y55B1BM.1
See related
AllianceGenome:WB:WBGene00021910
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables calcium channel regulator activity and identical protein binding activity. Involved in several processes, including ovulation; positive regulation of engulfment of apoptotic cell; and store-operated calcium entry. Located in several cellular components, including dendrite; neuronal cell body; and plasma membrane. Is expressed in gonadal sheath cell; intestine; spermatheca; and uterine toroidal epithelial cell. Human ortholog(s) of this gene implicated in Stormorken syndrome; gastrointestinal system cancer (multiple); immunodeficiency 10; lung cancer; and tubular aggregate myopathy 1. Orthologous to several human genes including STIM1 (stromal interaction molecule 1). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See stim-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
12
Sequence:
Chromosome: III; NC_003281.10 (408126..418749, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Secreted protein Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase Neighboring gene Chromo domain-containing protein Neighboring gene AF4/FMR2 C-terminal homology domain-containing protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Coordination of a Single Calcium Ion in the EF-hand Maintains the Off State of the Stromal Interaction Molecule Luminal Domain. Enomoto M, et al. J Mol Biol, 2020 Jan 17. PMID 31626806
  2. An aromatic amino acid in the coiled-coil 1 domain plays a crucial role in the auto-inhibitory mechanism of STIM1. Yu J, et al. Biochem J, 2013 Sep 15. PMID 23795811
  3. Mechanism of different spatial distributions of Caenorhabditis elegans and human STIM1 at resting state. Gao S, et al. Cell Calcium, 2009 Jan. PMID 18667236
  4. Distinct gating mechanism of SOC channel involving STIM-Orai coupling and an intramolecular interaction of Orai in Caenorhabditis elegans. Kim KM, et al. Proc Natl Acad Sci U S A, 2018 May 15. PMID 29712850, Free PMC Article
  5. Physiological roles of STIM1 and Orai1 homologs and CRAC channels in the genetic model organism Caenorhabditis elegans. Strange K, et al. Cell Calcium, 2007 Aug. PMID 17376526, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. we determined the X-ray crystal structure of the C. elegans STIM luminal domain, revealing that EF-SAM binds a single Ca(2+) ion with pentagonal bipyramidal geometry and an ancillary alpha-helix formed by the N-terminal region acts as a brace to stabilize EF-SAM.
    Title: Coordination of a Single Calcium Ion in the EF-hand Maintains the Off State of the Stromal Interaction Molecule Luminal Domain.
  2. Tyrosine316 may be involved in the auto-inhibitory mechanism of the STIM1 C-terminus in the quiescent state.
    Title: An aromatic amino acid in the coiled-coil 1 domain plays a crucial role in the auto-inhibitory mechanism of STIM1.
  3. Functional studies suggest that the inhibitory helix may keep the C-terminus of STIM1 in an inactive state.
    Title: Structural and mechanistic insights into the activation of Stromal interaction molecule 1 (STIM1).
  4. This review describes the role of STIM1 in Ca(2+) release activated Ca(2+) (CRAC) channel activity in worm gonad and intestine.
    Title: Physiological roles of STIM1 and Orai1 homologs and CRAC channels in the genetic model organism Caenorhabditis elegans.
  5. This study characterizes STIM-1 function in an intact animal and suggests that store-operated Ca(2+) entry is not essential for certain oscillatory Ca(2+) signaling processes and for maintenance of store Ca(2+) levels in C. elegans.
    Title: Function of a STIM1 homologue in C. elegans: evidence that store-operated Ca2+ entry is not essential for oscillatory Ca2+ signaling and ER Ca2+ homeostasis.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium channel regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium channel regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ovulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of engulfment of apoptotic cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transport IEA
Inferred from Electronic Annotation
more info
  
involved_in reproductive process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in store-operated calcium entry IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in store-operated calcium entry IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular organelle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
Stromal interaction molecule 1
NP_001022916.1
  • Confirmed by transcript evidence
NP_741073.1
  • Confirmed by transcript evidence
NP_741074.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    408126..418749 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171065.6 → NP_741073.1  Stromal interaction molecule 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741073.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EF60
    Conserved Domains (2) summary
    pfam16533
    Location:287 → 386
    SOAR; STIM1 Orai1-activating region
    cl15755
    Location:109 → 182
    SAM_superfamily; SAM (Sterile alpha motif )

  2. NM_171858.6 → NP_741074.1  Stromal interaction molecule 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741074.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EF60, H2L0R4, H2L0R5
    Conserved Domains (2) summary
    pfam16533
    Location:287 → 386
    SOAR; STIM1 Orai1-activating region
    cl15755
    Location:109 → 182
    SAM_superfamily; SAM (Sterile alpha motif )

  3. NM_001027745.7 → NP_001022916.1  Stromal interaction molecule 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022916.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EF60
    Conserved Domains (2) summary
    pfam16533
    Location:287 → 386
    SOAR; STIM1 Orai1-activating region
    cl15755
    Location:109 → 182
    SAM_superfamily; SAM (Sterile alpha motif )
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5EF60.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.