helq-1 Helicase POLQ-like [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: helq-1
Official Full Name: Helicase POLQ-like
Primary source: WormBase:WBGene00021905
Locus tag: CELE_Y55B1AL.3
See related: AllianceGenome:WB:WBGene00021905
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables ATPase binding activity and single-stranded DNA helicase activity. Involved in double-strand break repair and resolution of meiotic recombination intermediates. Predicted to be located in chromosome and nucleus. Orthologous to human HELQ (helicase, POLQ like). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See helq-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 12

Sequence:: Chromosome: III; NC_003281.10 (577684..587109, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Helicase Q promotes homology-driven DNA double-strand break repair and prevents tandem duplications.
Title: Helicase Q promotes homology-driven DNA double-strand break repair and prevents tandem duplications.
Analyses of jmjd-5 genetic interactions with genes required for resolving recombination intermediates (rtel-1) or promoting the resolution of RAD-51 double stranded DNA filaments (rfs-1 and helq-1) suggest that jmjd-5 prevents the formation of stalled postsynaptic recombination intermediates and favors RAD-51 removal.
Title: JMJD-5/KDM8 regulates H3K36me2 and is required for late steps of homologous recombination and genome integrity.
HELQ-1 and RFS-1 independently bind to and promote the disassembly of RAD-51 from double-stranded, but not single-stranded, DNA filaments via distinct mechanisms.
Title: Overlapping mechanisms promote postsynaptic RAD-51 filament disassembly during meiotic double-strand break repair.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y55B1A_116.b (e-PCR)
- UniSTS:323110

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA helicase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA double-strand break processing involved in repair via single-strand annealing	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA duplex unwinding	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via alternative nonhomologous end joining	IDA Inferred from Direct Assay more info	PubMed
involved_in double-strand break repair via synthesis-dependent strand annealing	IDA Inferred from Direct Assay more info	PubMed
involved_in resolution of meiotic recombination intermediates	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Helicase POLQ-like

NP_001022911.1

Confirmed by transcript evidence

NP_001379571.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

577684..587109 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001027740.7 → NP_001022911.1 Helicase POLQ-like [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022911.1

Status: REVIEWED

UniProtKB/Swiss-Prot

H2KY86, Q65XX0

Conserved Domains (2) summary

COG1204
Location:134 → 896

BRR2; Replicative superfamily II helicase [Replication, recombination and repair]

cd18026
Location:151 → 352

DEXHc_POLQ-like; DEXH-box helicase domain of DNA polymerase theta
NM_001393258.1 → NP_001379571.1 Helicase POLQ-like [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (2) summary

COG1204
Location:5 → 442

BRR2; Replicative superfamily II helicase [Replication, recombination and repair]

cd18795
Location:6 → 97

SF2_C_Ski2; C-terminal helicase domain of the Ski2 family helicases