U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

dac-1 Dachshund homolog dac-1 [ Caenorhabditis elegans ]

Gene ID: 175238, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
dac-1
Official Full Name
Dachshund homolog dac-1
Primary source
WormBase:WBGene00000895
Locus tag
CELE_B0412.1
See related
AllianceGenome:WB:WBGene00000895
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in thermotaxis. Located in nucleus. Is expressed in amphid neurons; cuticular ala; head neurons; seam cell; and tail. Orthologous to several human genes including DACH1 (dachshund family transcription factor 1). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See dac-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
10
Sequence:
Chromosome: III; NC_003281.10 (816145..821730)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Foie-gras_1 domain-containing protein;TRAPP II complex TRAPPC10 C-terminal domain-containing protein;Trafficking protein particle complex subunit 11 domain-containing protein Neighboring gene Dauer larva development regulatory growth factor daf-7 Neighboring gene ncRNA Neighboring gene C-type lectin domain-containing protein Neighboring gene Epoxide hydrolase 1

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification of thermosensory and olfactory neuron-specific genes via expression profiling of single neuron types. Colosimo ME, et al. Curr Biol, 2004 Dec 29. PMID 15620651
  2. Molecular encoding of stimulus features in a single sensory neuron type enables neuronal and behavioral plasticity. Harris N, et al. Curr Biol, 2023 Apr 24. PMID 36977417, Free PMC Article
  3. The Caenorhabditis elegans heterochronic regulator LIN-14 is a novel transcription factor that controls the developmental timing of transcription from the insulin/insulin-like growth factor gene ins-33 by direct DNA binding. Hristova M, et al. Mol Cell Biol, 2005 Dec. PMID 16314527, Free PMC Article
  4. A conserved Six-Eya cassette acts downstream of Wnt signaling to direct non-myogenic versus myogenic fates in the C. elegans postembryonic mesoderm. Amin NM, et al. Dev Biol, 2009 Jul 15. PMID 19427847, Free PMC Article
  5. The regulatory content of intergenic DNA shapes genome architecture. Nelson CE, et al. Genome Biol, 2004. PMID 15059258, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. dac-1 is expressed in a subset of sensory neurons including the AFD thermosensory neurons and is regulated by the TTX-1 OTX homeodomain protein.
    Title: Identification of thermosensory and olfactory neuron-specific genes via expression profiling of single neuron types.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in thermotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Dachshund homolog dac-1
NP_001021129.1
  • Confirmed by transcript evidence
NP_001021130.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    816145..821730
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001025958.4 → NP_001021129.1  Dachshund homolog dac-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021129.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H2KY91, Q86GT3
    Conserved Domains (1) summary
    cd21081
    Location:84 → 176
    DHD_Dac; Dachshund-homology domain found in the retinal determination protein Dachshund and similar proteins

  2. NM_001025959.5 → NP_001021130.1  Dachshund homolog dac-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021130.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86GT3
    Conserved Domains (1) summary
    pfam02437
    Location:1 → 73
    Ski_Sno; SKI/SNO/DAC family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
H2KY91.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools