K02F3.12 Putative ATP-dependent DNA helicase Q1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: K02F3.12
Official Full Name: Putative ATP-dependent DNA helicase Q1
Primary source: WormBase:WBGene00019334
Locus tag: CELE_K02F3.12
See related: AllianceGenome:WB:WBGene00019334
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable 3'-5' DNA helicase activity and four-way junction helicase activity. Predicted to be involved in DNA unwinding involved in DNA replication and double-strand break repair via homologous recombination. Predicted to be located in nucleus. Predicted to be active in chromosome and cytoplasm. Human ortholog(s) of this gene implicated in hepatocellular carcinoma; lung cancer; and pancreatic cancer. Orthologous to human RECQL (RecQ like helicase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See K02F3.12 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 5

Sequence:: Chromosome: III; NC_003281.10 (856560..860090)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K02F3.1 (e-PCR)
- UniSTS:311374

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 3'-5' DNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables four-way junction helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA geometric change	IEA Inferred from Electronic Annotation more info
involved_in DNA recombination	IEA Inferred from Electronic Annotation more info
involved_in DNA unwinding involved in DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in chromosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Putative ATP-dependent DNA helicase Q1

NP_001022656.1

Confirmed by transcript evidence

NP_001022657.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

856560..860090

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001027485.3 → NP_001022656.1 Putative ATP-dependent DNA helicase Q1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022656.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q5DX50, Q9TXJ8

Conserved Domains (4) summary

TIGR00614
Location:99 → 571

recQ_fam; ATP-dependent DNA helicase, RecQ family

cd00079
Location:303 → 435

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

pfam00270
Location:111 → 281

DEAD; DEAD/DEAH box helicase

pfam16124
Location:440 → 496

RecQ_Zn_bind; RecQ zinc-binding
NM_001027486.5 → NP_001022657.1 Putative ATP-dependent DNA helicase Q1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022657.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9TXJ8

Conserved Domains (4) summary

TIGR00614
Location:76 → 548

recQ_fam; ATP-dependent DNA helicase, RecQ family

cd00079
Location:280 → 412

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

pfam00270
Location:88 → 258

DEAD; DEAD/DEAH box helicase

pfam16124
Location:417 → 473

RecQ_Zn_bind; RecQ zinc-binding