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pef-1 Serine/threonine-protein phosphatase with EF-hands pef-1 [ Caenorhabditis elegans ]

Gene ID: 175257, updated on 2-Nov-2024

Summary

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Official Symbol
pef-1
Official Full Name
Serine/threonine-protein phosphatase with EF-hands pef-1
Primary source
WormBase:WBGene00003969
Locus tag
CELE_F23H11.8
See related
AllianceGenome:WB:WBGene00003969
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in detection of stimulus involved in sensory perception. Located in neuronal cell body. Is expressed in hypodermis; intestinal cell; muscle cell; and neurons. Orthologous to several human genes including PPEF1 (protein phosphatase with EF-hand domain 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pef-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
7
Sequence:
Chromosome: III; NC_003281.10 (919526..926316, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene DUF148 domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene DUF38 domain-containing protein;F-box domain-containing protein Neighboring gene DUF38 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cellular and subcellular localization, N-terminal acylation, and calcium binding of Caenorhabditis elegans protein phosphatase with EF-hands. Ramulu P, et al. J Biol Chem, 2001 Jul 6. PMID 11312268
  2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in detection of stimulus involved in sensory perception IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Serine/threonine-protein phosphatase with EF-hands pef-1
NP_001254836.1
  • Confirmed by transcript evidence
NP_001379892.1
  • Confirmed by transcript evidence
NP_741091.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    919526..926316 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001393271.1 → NP_001379892.1  Serine/threonine-protein phosphatase with EF-hands pef-1 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (2) summary
    cd00051
    Location:499 → 564
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd07420
    Location:64 → 380
    MPP_RdgC; Drosophila melanogaster RdgC and related proteins, metallophosphatase domain

  2. NM_171080.7 → NP_741091.1  Serine/threonine-protein phosphatase with EF-hands pef-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741091.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C3JXD7, G5EBX9, Q8MYR2
    Conserved Domains (4) summary
    smart00156
    Location:218 → 514
    PP2Ac; Protein phosphatase 2A homologues, catalytic domain
    cd00051
    Location:634 → 699
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd07420
    Location:199 → 515
    MPP_RdgC; Drosophila melanogaster RdgC and related proteins, metallophosphatase domain
    pfam13499
    Location:634 → 698
    EF-hand_7; EF-hand domain pair

  3. NM_001267907.3 → NP_001254836.1  Serine/threonine-protein phosphatase with EF-hands pef-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254836.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EBX9
    Conserved Domains (2) summary
    cd00051
    Location:569 → 634
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd07420
    Location:134 → 450
    MPP_RdgC; Drosophila melanogaster RdgC and related proteins, metallophosphatase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5EBX9.1

Gene LinkOut

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