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rab-18 Ras-related protein Rab-18 [ Caenorhabditis elegans ]

Gene ID: 175272, updated on 2-Nov-2024

Summary

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Official Symbol
rab-18
Official Full Name
Ras-related protein Rab-18
Primary source
WormBase:WBGene00004277
Locus tag
CELE_Y92C3B.3
See related
AllianceGenome:WB:WBGene00004277
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable GTPase activity. Predicted to be involved in intracellular protein transport and lipid droplet organization. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in Warburg micro syndrome 3. Orthologous to human RAB18 (RAB18, member RAS oncogene family). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rab-18 in Genome Data Viewer
Location:
chromosome: III
Exon count:
4
Sequence:
Chromosome: III; NC_003281.10 (1079466..1080481, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Methyltransf_21 domain-containing protein;Methyltransferase FkbM domain-containing protein Neighboring gene Splicing factor U2AF 65 kDa subunit Neighboring gene ncRNA Neighboring gene KNL (kinetochore null) Binding Protein Neighboring gene RING-type domain-containing protein Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The small GTPase RAB-18 is involved in regulating development/diapause by recruiting the intestinal cholesterol transporter NCR-1 onto the apical side in Caenorhabditis elegans. Awazu T, et al. Biochem Biophys Res Commun, 2024 Nov 19. PMID 39232459
  2. Cloning of Caenorhabditis U2AF65: an alternatively spliced RNA containing a novel exon. Zorio DA, et al. Mol Cell Biol, 1997 Feb. PMID 9001248, Free PMC Article
  3. C. elegans rab-18 mutants display reduced lipid content under fed and fasted conditions. Ratemi Z, et al. MicroPubl Biol, 2019 Dec 27. PMID 32550463, Free PMC Article
  4. The RBG-1-RBG-2 complex modulates autophagy activity by regulating lysosomal biogenesis and function in C. elegans. Wang Z, et al. J Cell Sci, 2019 Oct 1. PMID 31444285
  5. A Flexible Network of Lipid Droplet Associated Proteins Support Embryonic Integrity of C. elegans. Cao Z, et al. Front Cell Dev Biol, 2022. PMID 35445028, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The small GTPase RAB-18 is involved in regulating development/diapause by recruiting the intestinal cholesterol transporter NCR-1 onto the apical side in Caenorhabditis elegans.
    Title: The small GTPase RAB-18 is involved in regulating development/diapause by recruiting the intestinal cholesterol transporter NCR-1 onto the apical side in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid droplet organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Ras-related protein Rab-18
NP_741092.1
  • Confirmed by transcript evidence
NP_741093.2
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    1079466..1080481 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171081.7 → NP_741092.1  Ras-related protein Rab-18 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741092.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MXS1, Q9BL22
    Conserved Domains (1) summary
    cd01863
    Location:12 → 172
    Rab18; Rab GTPase family 18 (Rab18)

  2. NM_171861.6 → NP_741093.2  Ras-related protein Rab-18 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741093.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MXS1
    Conserved Domains (2) summary
    pfam00071
    Location:1 → 164
    Ras; Ras family
    cl21455
    Location:1 → 162
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MXS1.1

Gene LinkOut

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