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acsd-1 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase [ Caenorhabditis elegans ]

Gene ID: 175280, updated on 2-Nov-2024

Summary

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Official Symbol
acsd-1
Official Full Name
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
Primary source
WormBase:WBGene00022104
Locus tag
CELE_Y71D11A.3
See related
AllianceGenome:WB:WBGene00022104
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable aminocarboxymuconate-semialdehyde decarboxylase activity. Predicted to be involved in negative regulation of quinolinate biosynthetic process and secondary metabolic process. Predicted to be active in cytosol. Orthologous to human ACMSD (aminocarboxymuconate semialdehyde decarboxylase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See acsd-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
10
Sequence:
Chromosome: III; NC_003281.10 (1116466..1142927)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Excretory canal abnormal protein 6 Neighboring gene Fungal lipase-like domain-containing protein Neighboring gene ncRNA Neighboring gene putative ligand-gated ion channel 46 Neighboring gene ncRNA Neighboring gene Tudor domain-containing protein Neighboring gene Cadherin domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. De novo NAD(+) synthesis enhances mitochondrial function and improves health. Katsyuba E, et al. Nature, 2018 Nov. PMID 30356218, Free PMC Article
  2. High-throughput behavioral analysis in C. elegans. Swierczek NA, et al. Nat Methods, 2011 Jun 5. PMID 21642964, Free PMC Article
  3. Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain. Dube F, et al. PLoS One, 2023. PMID 37141255, Free PMC Article
  4. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
  5. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables aminocarboxymuconate-semialdehyde decarboxylase activity IEA
Inferred from Electronic Annotation
more info
  
enables aminocarboxymuconate-semialdehyde decarboxylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of quinolinate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of quinolinate biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in secondary metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
NP_001022935.1
  • Confirmed by transcript evidence
NP_001360068.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    1116466..1142927
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001373845.2 → NP_001360068.1  2-amino-3-carboxymuconate-6-semialdehyde decarboxylase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95Y54
    Conserved Domains (1) summary
    pfam04909
    Location:57 → 342
    Amidohydro_2; Amidohydrolase

  2. NM_001027764.3 → NP_001022935.1  2-amino-3-carboxymuconate-6-semialdehyde decarboxylase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022935.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8T8B9
    Conserved Domains (1) summary
    pfam04909
    Location:57 → 391
    Amidohydro_2; Amidohydrolase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8T8B9.1

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