U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

sms-3 Putative phosphatidylcholine:ceramide cholinephosphotransferase 3;Sphingomyelin synthase-like domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 175313, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
sms-3
Official Full Name
Putative phosphatidylcholine:ceramide cholinephosphotransferase 3;Sphingomyelin synthase-like domain-containing protein
Primary source
WormBase:WBGene00004894
Locus tag
CELE_Y22D7AL.8
See related
AllianceGenome:WB:WBGene00004894
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ceramide cholinephosphotransferase activity and sphingomyelin synthase activity. Predicted to be involved in ceramide biosynthetic process and sphingomyelin biosynthetic process. Predicted to be located in membrane. Predicted to be active in Golgi membrane; endoplasmic reticulum membrane; and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See sms-3 in Genome Data Viewer
Location:
chromosome: III
Exon count:
8
Sequence:
Chromosome: III; NC_003281.10 (1583155..1601144, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Talin_middle domain-containing protein Neighboring gene tRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Met Neighboring gene tRNA-Glu

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Caenorhabditis elegans Heterochromatin protein 1 (HPL-2) links developmental plasticity, longevity and lipid metabolism. Meister P, et al. Genome Biol, 2011 Dec 20. PMID 22185090, Free PMC Article
  2. Sphingolipid profiling reveals differential functions of sphingolipid biosynthesis isozymes of Caenorhabditis elegans. Luo H, et al. J Lipid Res, 2024 Jun. PMID 38704027, Free PMC Article
  3. Identification of a family of animal sphingomyelin synthases. Huitema K, et al. EMBO J, 2004 Jan 14. PMID 14685263, Free PMC Article
  4. The mechanoreceptor DEG-1 regulates cold tolerance in Caenorhabditis elegans. Takagaki N, et al. EMBO Rep, 2020 Mar 4. PMID 32009302, Free PMC Article
  5. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ceramide cholinephosphotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ceramide cholinephosphotransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables phosphotransferase activity, for other substituted phosphate groups IEA
Inferred from Electronic Annotation
more info
  
enables sphingomyelin synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sphingomyelin synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ceramide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sphingomyelin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sphingomyelin biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Putative phosphatidylcholine:ceramide cholinephosphotransferase 3;Sphingomyelin synthase-like domain-containing protein
NP_001317879.1
  • Confirmed by transcript evidence
NP_001317880.1
  • Confirmed by transcript evidence
NP_001317881.1
  • Confirmed by transcript evidence
NP_001317882.1
  • Confirmed by transcript evidence
NP_001380062.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    1583155..1601144 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001393283.1 → NP_001380062.1  Putative phosphatidylcholine:ceramide cholinephosphotransferase 3 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q965Q4
    Conserved Domains (1) summary
    pfam14360
    Location:174 → 247
    PAP2_C; PAP2 superfamily C-terminal

  2. NM_001330977.3 → NP_001317879.1  Sphingomyelin synthase-like domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1C3NSL0
    Conserved Domains (1) summary
    pfam14360
    Location:259 → 332
    PAP2_C; PAP2 superfamily C-terminal

  3. NM_001330978.3 → NP_001317880.1  Sphingomyelin synthase-like domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1C3NSK5
    Conserved Domains (1) summary
    pfam14360
    Location:194 → 267
    PAP2_C; PAP2 superfamily C-terminal

  4. NM_001330979.3 → NP_001317881.1  Sphingomyelin synthase-like domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1C3NSJ8
    Conserved Domains (1) summary
    pfam14360
    Location:208 → 281
    PAP2_C; PAP2 superfamily C-terminal

  5. NM_001330980.3 → NP_001317882.1  Sphingomyelin synthase-like domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1C3NSJ9
    Conserved Domains (1) summary
    pfam14360
    Location:2 → 75
    PAP2_C; PAP2 superfamily C-terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q965Q4.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools