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ttc-7 TPR_REGION domain-containing protein;Tetratricopeptide repeat protein 7 N-terminal domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 175332, updated on 2-Nov-2024

Summary

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Official Symbol
ttc-7
Official Full Name
TPR_REGION domain-containing protein;Tetratricopeptide repeat protein 7 N-terminal domain-containing protein
Primary source
WormBase:WBGene00021444
Locus tag
CELE_Y39A3CR.3
See related
AllianceGenome:WB:WBGene00021444
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in phosphatidylinositol phosphate biosynthetic process and protein localization to plasma membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including anal depressor muscle; coelomocyte; excretory cell; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in multiple intestinal atresia. Orthologous to human TTC7A (tetratricopeptide repeat domain 7A) and TTC7B (tetratricopeptide repeat domain 7B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ttc-7 in Genome Data Viewer
Location:
chromosome: III
Exon count:
14
Sequence:
Chromosome: III; NC_003281.10 (1860429..1877886)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene BHLH domain-containing protein Neighboring gene Mitochondrial import inner membrane translocase subunit Tim8 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Gem-associated protein 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
  2. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
  3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
TPR_REGION domain-containing protein;Tetratricopeptide repeat protein 7 N-terminal domain-containing protein
NP_001254845.1
  • Confirmed by transcript evidence
NP_001254846.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    1860429..1877886
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001267916.2 → NP_001254845.1  Tetratricopeptide repeat protein 7 N-terminal domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254845.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KYB6
    Conserved Domains (2) summary
    TIGR02917
    Location:508 → 951
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:888 → 915
    TPR; TPR repeat [structural motif]

  2. NM_001267917.3 → NP_001254846.1  TPR_REGION domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254846.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F8WU09
    Conserved Domains (2) summary
    TIGR02917
    Location:112 → 555
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:412 → 440
    TPR; TPR repeat [structural motif]
Nucleotide Protein
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