polh-1 DNA polymerase eta [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: polh-1
Official Full Name: DNA polymerase eta
Primary source: WormBase:WBGene00018721
Locus tag: CELE_F53A3.2
See related: AllianceGenome:WB:WBGene00018721
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA-directed DNA polymerase activity. Involved in embryo development; error-prone translesion synthesis; and negative regulation of mitotic DNA damage checkpoint. Located in nucleus. Human ortholog(s) of this gene implicated in female breast cancer and xeroderma pigmentosum variant type. Orthologous to human POLH (DNA polymerase eta). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See polh-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 9

Sequence:: Chromosome: III; NC_003281.10 (1945058..1950269, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SUMO-mediated regulation of both POLH-1 and POLK-1, and point towards a previously unrecognized role of the nuclear pore in regulating Translesion synthesis .
Title: A broad requirement for TLS polymerases η and κ, and interacting sumoylation and nuclear pore proteins, in lesion bypass during C. elegans embryogenesis.
These studies reveal that POLH-1 undergoes DNA-damage-induced proteolysis and that GEI-17 regulates the timing of this proteolysis.
Title: Regulated proteolysis of DNA polymerase eta during the DNA-damage response in C. elegans.
findings indicate that Poleta contributes significantly to damage tolerance in early embryogenesis but only modestly at later stages; may confer UV resistance perhaps by catalyzing translesion synthesis in early embryogenesis
Title: Deficiency of the Caenorhabditis elegans DNA polymerase eta homologue increases sensitivity to UV radiation during germ-line development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F53A3.2 (e-PCR)
- UniSTS:312612

F53A3.3 (e-PCR)
- UniSTS:315888

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA-directed DNA polymerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables damaged DNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in embryo development ending in birth or egg hatching	IGI Inferred from Genetic Interaction more info	PubMed
involved_in error-prone translesion synthesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in error-prone translesion synthesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in error-prone translesion synthesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macromolecule biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of mitotic DNA damage checkpoint	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nucleobase-containing compound biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in postreplication repair	IEA Inferred from Electronic Annotation more info
involved_in reproductive process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to radiation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in replication fork	IBA Inferred from Biological aspect of Ancestor more info
is_active_in site of double-strand break	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: DNA polymerase eta

NP_497480.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

1945058..1950269 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065079.4 → NP_497480.2 DNA polymerase eta [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497480.2

Status: REVIEWED

UniProtKB/TrEMBL

G5EFY1

Conserved Domains (1) summary

cl28996
Location:7 → 426

PolY; Y-family of DNA polymerases