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ckr-2 G-protein coupled receptors family 1 profile domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 175341, updated on 2-Nov-2024

Summary

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Official Symbol
ckr-2
Official Full Name
G-protein coupled receptors family 1 profile domain-containing protein
Primary source
WormBase:WBGene00021439
Locus tag
CELE_Y39A3B.5
See related
AllianceGenome:WB:WBGene00021439
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables neuropeptide binding activity. Involved in determination of adult lifespan and neuropeptide signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in neurons. Human ortholog(s) of this gene implicated in obesity; pancreatic cancer; and panic disorder. Orthologous to several human genes including CCKAR (cholecystokinin A receptor). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ckr-2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
13
Sequence:
Chromosome: III; NC_003281.10 (2009299..2021595, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene tRNA Neighboring gene Ligand-Gated ion Channel Neighboring gene Peptidase M28 domain-containing protein Neighboring gene ncRNA Neighboring gene tRNA-Glu Neighboring gene tRNA-Glu Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A pharmacological study of NLP-12 neuropeptide signaling in free-living and parasitic nematodes. Peeters L, et al. Peptides, 2012 Mar. PMID 22019590
  2. A conserved neuropeptide system links head and body motor circuits to enable adaptive behavior. Ramachandran S, et al. Elife, 2021 Nov 12. PMID 34766905, Free PMC Article
  3. A neuropeptide-mediated stretch response links muscle contraction to changes in neurotransmitter release. Hu Z, et al. Neuron, 2011 Jul 14. PMID 21745640, Free PMC Article
  4. NLP-12 engages different UNC-13 proteins to potentiate tonic and evoked release. Hu Z, et al. J Neurosci, 2015 Jan 21. PMID 25609620, Free PMC Article
  5. Discovery of a cholecystokinin-gastrin-like signaling system in nematodes. Janssen T, et al. Endocrinology, 2008 Jun. PMID 18339709

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A conserved neuropeptide system links head and body motor circuits to enable adaptive behavior.
    Title: A conserved neuropeptide system links head and body motor circuits to enable adaptive behavior.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables neuropeptide binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables neuropeptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuropeptide signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
G-protein coupled receptors family 1 profile domain-containing protein
NP_001293648.1
  • Confirmed by transcript evidence
NP_001367972.1
  • Confirmed by transcript evidence
NP_001367973.1
  • Confirmed by transcript evidence
NP_001367974.1
  • Confirmed by transcript evidence
NP_001370897.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    2009299..2021595 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001381755.2 → NP_001367974.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G4SNP8
    Conserved Domains (1) summary
    cd14993
    Location:61 → 411
    7tmA_CCKR-like; cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001384036.1 → NP_001370897.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    B2L044
    Conserved Domains (1) summary
    cd14993
    Location:19 → 369
    7tmA_CCKR-like; cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. NM_001381757.1 → NP_001367972.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5ECU0
    Conserved Domains (1) summary
    cd14993
    Location:19 → 466
    7tmA_CCKR-like; cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

  4. NM_001381756.1 → NP_001367973.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G4SNR2
    Conserved Domains (1) summary
    cd14993
    Location:61 → 508
    7tmA_CCKR-like; cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

  5. NM_001306719.3 → NP_001293648.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293648.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B2L045
    Conserved Domains (1) summary
    cd14993
    Location:19 → 369
    7tmA_CCKR-like; cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein
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