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Y48G9A.9 Protein-tyrosine phosphatase [ Caenorhabditis elegans ]

Gene ID: 175343, updated on 2-Nov-2024

Summary

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Official Symbol
Y48G9A.9
Official Full Name
Protein-tyrosine phosphatase
Primary source
WormBase:WBGene00021702
Locus tag
CELE_Y48G9A.9
See related
AllianceGenome:WB:WBGene00021702
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in motor neuron axon guidance and signal transduction. Orthologous to human PTPN7 (protein tyrosine phosphatase non-receptor type 7); PTPRG (protein tyrosine phosphatase receptor type G); and PTPRZ1 (protein tyrosine phosphatase receptor type Z1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See Y48G9A.9 in Genome Data Viewer
Location:
chromosome: III
Exon count:
8
Sequence:
Chromosome: III; NC_003281.10 (2092709..2099881)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Tyrosine-protein phosphatase domain-containing protein Neighboring gene pseudo Neighboring gene Choline/carnitine acyltransferase domain-containing protein Neighboring gene PIPK domain-containing protein Neighboring gene CsbD family protein;Late embryogenesis abundant protein D-29-like Neighboring gene C2H2-type domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
  2. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in motor neuron axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Protein-tyrosine phosphatase
NP_001022892.1
  • Confirmed by transcript evidence
NP_001022893.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    2092709..2099881
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027721.4 → NP_001022892.1  Protein-tyrosine phosphatase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022892.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KZ95
    Conserved Domains (2) summary
    smart00194
    Location:62 → 321
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:88 → 321
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

  2. NM_001027722.3 → NP_001022893.1  Protein-tyrosine phosphatase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022893.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7YZG5
    Conserved Domains (2) summary
    smart00194
    Location:71 → 330
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:97 → 330
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
Nucleotide Protein
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