U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ppk-2 PIPK domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 175344, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
ppk-2
Official Full Name
PIPK domain-containing protein
Primary source
WormBase:WBGene00004088
Locus tag
CELE_Y48G9A.8
See related
AllianceGenome:WB:WBGene00004088
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable 1-phosphatidylinositol-4-phosphate 5-kinase activity. Predicted to be involved in phosphatidylinositol phosphate biosynthetic process. Predicted to be active in plasma membrane. Is expressed in several structures, including enteric muscle; excretory cell; nervous system; rectum; and reproductive system. Orthologous to several human genes including PIP4K2A (phosphatidylinositol-5-phosphate 4-kinase type 2 alpha). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ppk-2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
6
Sequence:
Chromosome: III; NC_003281.10 (2102295..2107497)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Choline/carnitine acyltransferase domain-containing protein Neighboring gene Protein-tyrosine phosphatase Neighboring gene CsbD family protein;Late embryogenesis abundant protein D-29-like Neighboring gene C2H2-type domain-containing protein Neighboring gene Conserved secreted protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Overexpression of PPK-1, the Caenorhabditis elegans Type I PIP kinase, inhibits growth cone collapse in the developing nervous system and causes axonal degeneration in adults. Weinkove D, et al. Dev Biol, 2008 Jan 1. PMID 18037397, Free PMC Article
  2. Role of phosphatidylinositol-4-phosphate 5' kinase (ppk-1) in ovulation of Caenorhabditis elegans. Xu X, et al. Exp Cell Res, 2007 Jul 1. PMID 17475243, Free PMC Article
  3. Evolutionarily conserved structural changes in phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) isoforms are responsible for differences in enzyme activity and localization. Clarke JH, et al. Biochem J, 2013 Aug 15. PMID 23758345, Free PMC Article
  4. RTKN-1/Rhotekin shields endosome-associated F-actin from disassembly to ensure endocytic recycling. Yan Y, et al. J Cell Biol, 2021 May 3. PMID 33844824, Free PMC Article
  5. The Rho/Rac-family guanine nucleotide exchange factor VAV-1 regulates rhythmic behaviors in C. elegans. Norman KR, et al. Cell, 2005 Oct 7. PMID 16213217

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables 1-phosphatidylinositol-5-phosphate 4-kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in phosphatidylinositol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
PIPK domain-containing protein
NP_497500.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    2102295..2107497
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065099.5 → NP_497500.1  PIPK domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497500.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9BL73
    Conserved Domains (1) summary
    cd17305
    Location:30 → 398
    PIPKc_PIP5KII; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in type II phosphatidylinositol 5-phosphate 4-kinase (PIP5KII) and similar proteins
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous