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apb-1 AP complex subunit beta [ Caenorhabditis elegans ]

Gene ID: 175376, updated on 2-Nov-2024

Summary

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Official Symbol
apb-1
Official Full Name
AP complex subunit beta
Primary source
WormBase:WBGene00000160
Locus tag
CELE_Y71H2B.10
See related
AllianceGenome:WB:WBGene00000160
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable clathrin binding activity. Involved in embryo development and receptor-mediated endocytosis. Predicted to be located in cytoplasm and membrane. Predicted to be part of clathrin adaptor complex. Is expressed in nervous system and pharynx. Orthologous to several human genes including AP1B1 (adaptor related protein complex 1 subunit beta 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See apb-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
9
Sequence:
Chromosome: III; NC_003281.10 (2583971..2597034, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Phosphatidylinositol transfer protein Neighboring gene FTH domain-containing protein Neighboring gene G Protein, Alpha subunit Neighboring gene ncRNA Neighboring gene Mediator of RNA polymerase II transcription subunit 19 Neighboring gene BTB domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Distinct and redundant functions of mu1 medium chains of the AP-1 clathrin-associated protein complex in the nematode Caenorhabditis elegans. Shim J, et al. Mol Biol Cell, 2000 Aug. PMID 10930467, Free PMC Article
  2. Mu2 adaptin facilitates but is not essential for synaptic vesicle recycling in Caenorhabditis elegans. Gu M, et al. J Cell Biol, 2008 Dec 1. PMID 19047463, Free PMC Article
  3. Caenorhabditis elegans reveals a FxNPxY-independent low-density lipoprotein receptor internalization mechanism mediated by epsin1. Kang YL, et al. Mol Biol Cell, 2013 Feb. PMID 23242996, Free PMC Article
  4. Clathrin interaction and subcellular localization of Ce-DAB-1, an adaptor for protein secretion in Caenorhabditis elegans. Kamikura DM, et al. Traffic, 2006 Mar. PMID 16497226
  5. Clathrin and AP2 are required for phagocytic receptor-mediated apoptotic cell clearance in Caenorhabditis elegans. Chen D, et al. PLoS Genet, 2013 May. PMID 23696751, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables clathrin binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in receptor-mediated endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of clathrin adaptor complex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of membrane coat IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
AP complex subunit beta
NP_001022937.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    2583971..2597034 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027766.5 → NP_001022937.1  AP complex subunit beta [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022937.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9N4F3
    Conserved Domains (5) summary
    smart00809
    Location:736 → 834
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:844 → 955
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    pfam01602
    Location:11 → 531
    Adaptin_N; Adaptin N terminal region
    pfam12717
    Location:99 → 265
    Cnd1; non-SMC mitotic condensation complex subunit 1
    sd00044
    Location:51 → 75
    HEAT; HEAT repeat [structural motif]
Nucleotide Protein
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