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tufm-1 Elongation factor Tu, mitochondrial [ Caenorhabditis elegans ]

Gene ID: 175398, updated on 2-Nov-2024

Summary

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Official Symbol
tufm-1
Official Full Name
Elongation factor Tu, mitochondrial
Primary source
WormBase:WBGene00007000
Locus tag
CELE_Y71H2AM.23
See related
AllianceGenome:WB:WBGene00007000
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable translation elongation factor activity. Predicted to be involved in mitochondrial translational elongation. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 4. Orthologous to human TUFM (Tu translation elongation factor, mitochondrial). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tufm-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
4
Sequence:
Chromosome: III; NC_003281.10 (2812143..2814969, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Peptidase C1A papain C-terminal domain-containing protein Neighboring gene E3 ubiquitin-protein ligase E3D Neighboring gene Phosphatidylinositol-4,5-bisphosphate 4-phosphatase Neighboring gene N(6)-L-threonylcarbamoyladenine synthase Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. T-armless tRNAs and elongated elongation factor Tu. Ohtsuki T, et al. IUBMB Life, 2007 Feb. PMID 17454297
  2. A unique serine-specific elongation factor Tu found in nematode mitochondria. Ohtsuki T, et al. Nat Struct Biol, 2002 Sep. PMID 12145639
  3. A unique tRNA recognition mechanism of Caenorhabditis elegans mitochondrial EF-Tu2. Suematsu T, et al. Nucleic Acids Res, 2005. PMID 16113240, Free PMC Article
  4. A protein extension to shorten RNA: elongated elongation factor-Tu recognizes the D-arm of T-armless tRNAs in nematode mitochondria. Sakurai M, et al. Biochem J, 2006 Oct 15. PMID 16859488, Free PMC Article
  5. Identification of the residues involved in the unique serine specificity of Caenorhabditis elegans mitochondrial EF-Tu2. Sato A, et al. Biochemistry, 2006 Sep 12. PMID 16953577

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables translation elongation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation elongation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrial translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational elongation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Elongation factor Tu, mitochondrial
NP_497623.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    2812143..2814969 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065222.7 → NP_497623.1  Elongation factor Tu, mitochondrial [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497623.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5ECM6, Q7JQD2
    Conserved Domains (1) summary
    PRK00049
    Location:41 → 438
    PRK00049; elongation factor Tu; Reviewed
Nucleotide Protein
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