mec-12 Detyrosinated tubulin alpha-3 chain [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mec-12
Official Full Name: Detyrosinated tubulin alpha-3 chain
Primary source: WormBase:WBGene00003175
Locus tag: CELE_C44B11.3
See related: AllianceGenome:WB:WBGene00003175
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Involved in several processes, including detection of mechanical stimulus involved in sensory perception of touch; positive regulation of detection of mechanical stimulus involved in sensory perception of touch; and positive regulation of mechanosensory behavior. Located in axon; microtubule; and neuronal cell body. Is expressed in intestine; nervous system; and in male. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 22; keratoconus; lissencephaly (multiple); microcephaly; and visual epilepsy. Orthologous to several human genes including TUBA3C (tubulin alpha 3c) and TUBA3D (tubulin alpha 3d). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mec-12 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 5

Sequence:: Chromosome: III; NC_003281.10 (3131574..3139234, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

tubulin acetylation and microtubule protofilaments were unaffected in the mec-12(gm379) mutant. We hypothesize that the G416E substitution may alter the association of microtubule-binding proteins with microtubules
Title: Genetic analysis of a novel tubulin mutation that redirects synaptic vesicle targeting and causes neurite degeneration in C. elegans.
Acetylation of MEC-12 alpha-tubulin constrains protofilament number in C. elegans touch receptor neurons.
Title: Posttranslational acetylation of α-tubulin constrains protofilament number in native microtubules.
Data show that all mec-15 phenotypes can be dominantly suppressed by mutations in mec-7, which encodes a beta-tubulin, and dominantly enhanced by mutations in mec-12, which encodes an alpha-tubulin.
Title: mec-15 encodes an F-box protein required for touch receptor neuron mechanosensation, synapse formation and development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C44B11.3 (e-PCR)
- UniSTS:313865

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables structural constituent of cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of cytoskeleton	IEA Inferred from Electronic Annotation more info
enables structural constituent of cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in detection of mechanical stimulus involved in sensory perception of touch	IGI Inferred from Genetic Interaction more info	PubMed
involved_in detection of mechanical stimulus involved in sensory perception of touch	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mechanosensory behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mechanosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based process	IEA Inferred from Electronic Annotation more info
involved_in microtubule-based process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule-based process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of detection of mechanical stimulus involved in sensory perception of touch	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of mechanosensory behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to mechanical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in thigmotaxis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Detyrosinated tubulin alpha-3 chain

NP_497663.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

3131574..3139234 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065262.6 → NP_497663.1 Detyrosinated tubulin alpha-3 chain [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497663.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O01907, P91910, Q7JQD4, Q9TYG0

Conserved Domains (2) summary

PTZ00335
Location:1 → 448

PTZ00335; tubulin alpha chain; Provisional

cd02186
Location:2 → 435

alpha_tubulin; The alpha-tubulin family