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gei-1 START domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 175436, updated on 2-Nov-2024

Summary

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Official Symbol
gei-1
Official Full Name
START domain-containing protein
Primary source
WormBase:WBGene00001559
Locus tag
CELE_F45H7.2
See related
AllianceGenome:WB:WBGene00001559
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in actin cytoskeleton organization and regulation of Rho protein signal transduction. Is expressed in pharynx. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human DLC1 (DLC1 Rho GTPase activating protein); STARD13 (StAR related lipid transfer domain containing 13); and STARD8 (StAR related lipid transfer domain containing 8). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gei-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
26
Sequence:
Chromosome: III; NC_003281.10 (3344873..3363427)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Secreted protein Neighboring gene tRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Serine/threonine-protein kinase prk-2 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation of the interacting molecules with GEX-3 by a novel functional screening. Tsuboi D, et al. Biochem Biophys Res Commun, 2002 Apr 5. PMID 11922622
  2. Systematic analysis of genes required for synapse structure and function. Sieburth D, et al. Nature, 2005 Jul 28. PMID 16049479
  3. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
  4. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
START domain-containing protein
NP_001254868.1
  • Confirmed by transcript evidence
NP_001254869.1
  • Confirmed by transcript evidence
NP_497694.3
  • Confirmed by transcript evidence
NP_497695.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    3344873..3363427
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065294.6 → NP_497695.3  START domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497695.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q20442
    Conserved Domains (3) summary
    cd04375
    Location:876 → 1103
    RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...
    cl14643
    Location:1126 → 1325
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
    cl15755
    Location:444 → 499
    SAM_superfamily; SAM (Sterile alpha motif )

  2. NM_065293.6 → NP_497694.3  START domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497694.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q20440
    Conserved Domains (3) summary
    cd04375
    Location:1052 → 1279
    RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...
    cl14643
    Location:1302 → 1501
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
    cl15755
    Location:444 → 499
    SAM_superfamily; SAM (Sterile alpha motif )

  3. NM_001267939.3 → NP_001254868.1  START domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254868.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C7FZT8
    Conserved Domains (3) summary
    cd04375
    Location:883 → 1110
    RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...
    cl14643
    Location:1133 → 1332
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
    cl15755
    Location:275 → 330
    SAM_superfamily; SAM (Sterile alpha motif )

  4. NM_001267940.3 → NP_001254869.1  START domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254869.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C0P276
    Conserved Domains (1) summary
    cl14643
    Location:20 → 219
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
Nucleotide Protein
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