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cri-3 Conserved regulator of innate immunity protein 3 [ Caenorhabditis elegans ]

Gene ID: 175441, updated on 2-Nov-2024

Summary

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Official Symbol
cri-3
Official Full Name
Conserved regulator of innate immunity protein 3
Primary source
WormBase:WBGene00010303
Locus tag
CELE_F59A2.3
See related
AllianceGenome:WB:WBGene00010303
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in cytosolic ribosome assembly. Predicted to be located in mitochondrial matrix. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 33. Orthologous to human C1QBP (complement C1q binding protein). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cri-3 in Genome Data Viewer
Location:
chromosome: III
Exon count:
4
Sequence:
Chromosome: III; NC_003281.10 (3396585..3397627)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene E3 ubiquitin-protein ligase hecw-1 Neighboring gene tRNA-Lys Neighboring gene ncRNA Neighboring gene ELMO domain-containing protein;ELMO domain-containing protein C56G7.3 Neighboring gene Myosin regulatory light chain Neighboring gene Pre-mRNA cleavage complex subunit Clp1 C-terminal domain-containing protein;Protein clpf-1 Neighboring gene Nuclear Pore complex Protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SUMO peptidase ULP-4 regulates mitochondrial UPR-mediated innate immunity and lifespan extension. Gao K, et al. Elife, 2019 Jan 15. PMID 30642431, Free PMC Article
  2. Systematic interactome mapping and genetic perturbation analysis of a C. elegans TGF-beta signaling network. Tewari M, et al. Mol Cell, 2004 Feb 27. PMID 14992718
  3. Protein interaction mapping in C. elegans using proteins involved in vulval development. Walhout AJ, et al. Science, 2000 Jan 7. PMID 10615043
  4. SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells. Jackson J, et al. Mol Metab, 2022 Jul. PMID 35452878, Free PMC Article
  5. Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences. Zhang X, et al. PLoS Genet, 2021 Jun. PMID 34166401, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytosolic ribosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Conserved regulator of innate immunity protein 3
NP_001379055.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    3396585..3397627
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001393306.1 → NP_001379055.1  Conserved regulator of innate immunity protein 3 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q21018
    Conserved Domains (1) summary
    pfam02330
    Location:46 → 228
    MAM33; Mitochondrial glycoprotein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q21018.2

Gene LinkOut

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