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npp-9 Nuclear Pore complex Protein [ Caenorhabditis elegans ]

Gene ID: 175443, updated on 12-Jun-2024

Summary

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Gene symbol
npp-9
Gene description
Nuclear Pore complex Protein
Locus tag
CELE_F59A2.1
See related
AllianceGenome:WB:WBGene00003795
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable metal ion binding activity. Predicted to contribute to GTPase activator activity. Involved in embryo development and nucleus organization. Part of nuclear pore. Human ortholog(s) of this gene implicated in brain disease and inflammatory myofibroblastic tumor. Orthologous to several human genes including RANBP2 (RAN binding protein 2); RGPD1 (RANBP2 like and GRIP domain containing 1); and RGPD2 (RANBP2 like and GRIP domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See npp-9 in Genome Data Viewer
Location:
chromosome: III
Exon count:
8
Sequence:
Chromosome: III; NC_003281.10 (3400644..3404276, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Conserved regulator of innate immunity protein 3 Neighboring gene Pre-mRNA cleavage complex subunit Clp1 C-terminal domain-containing protein;Protein clpf-1 Neighboring gene ACT domain-containing protein Neighboring gene GRIP domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nup155 regulates nuclear envelope and nuclear pore complex formation in nematodes and vertebrates. Franz C, et al. EMBO J, 2005 Oct 19. PMID 16193066, Free PMC Article
  2. Perinuclear P granules are the principal sites of mRNA export in adult C. elegans germ cells. Sheth U, et al. Development, 2010 Apr. PMID 20223759, Free PMC Article
  3. Sm protein down-regulation leads to defects in nuclear pore complex disassembly and distribution in C. elegans embryos. Joseph-Strauss D, et al. Dev Biol, 2012 May 15. PMID 22426005, Free PMC Article
  4. Caenorhabditis elegans nucleoporins Nup93 and Nup205 determine the limit of nuclear pore complex size exclusion in vivo. Galy V, et al. Mol Biol Cell, 2003 Dec. PMID 12937276, Free PMC Article
  5. The USTC co-opts an ancient machinery to drive piRNA transcription in C. elegans. Weng C, et al. Genes Dev, 2019 Jan 1. PMID 30567997, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
contributes_to GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleus organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear pore IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Nuclear Pore complex Protein
NP_001369848.1
  • Confirmed by transcript evidence
NP_001370159.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    3400644..3404276 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001384053.2 → NP_001369848.1  Nuclear Pore complex Protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q21021
    Conserved Domains (5) summary
    smart00160
    Location:255 → 384
    RanBD; Ran-binding domain
    smart00547
    Location:438 → 462
    ZnF_RBZ; Zinc finger domain
    sd00029
    Location:440 → 459
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam05109
    Location:147 → 233
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam15967
    Location:534 → 699
    Nucleoporin_FG2; Nucleoporin FG repeated region

  2. NM_001384054.1 → NP_001370159.1  Nuclear Pore complex Protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86G90
    Conserved Domains (5) summary
    smart00160
    Location:750 → 880
    RanBD; Ran-binding domain
    smart00547
    Location:462 → 486
    ZnF_RBZ; Zinc finger domain
    sd00029
    Location:464 → 483
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam05109
    Location:147 → 233
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam15967
    Location:547 → 723
    Nucleoporin_FG2; Nucleoporin FG repeated region
Nucleotide Protein
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