unc-93 Putative potassium channel regulatory protein unc-93 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: unc-93
Official Full Name: Putative potassium channel regulatory protein unc-93
Primary source: WormBase:WBGene00006822
Locus tag: CELE_C46F11.1
See related: AllianceGenome:WB:WBGene00006822
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables potassium channel regulator activity. Involved in regulation of muscle contraction and regulation of potassium ion transport. Located in plasma membrane and striated muscle dense body. Is expressed in SIA; body wall musculature; and non-striated muscle. Orthologous to human UNC93A (unc-93 homolog A). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See unc-93 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 16

Sequence:: Chromosome: III; NC_003281.10 (3644375..3648822)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that loss-of-function mutations in the nonessential splicing factor smu-2 and smu-1 suppress unc-73 e936 uncoordination through changes in splicing.
Title: A genetic screen for suppressors of a mutated 5' splice site identifies factors associated with later steps of spliceosome assembly.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C46F11.1 (e-PCR)
- UniSTS:307343

ha2152 (e-PCR)
- UniSTS:515493

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables potassium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel regulator activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of potassium ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of potassium ion transport	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in striated muscle dense body	IBA Inferred from Biological aspect of Ancestor more info
located_in striated muscle dense body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Putative potassium channel regulatory protein unc-93

NP_001021218.1

Partially confirmed by transcript evidence

NP_001366876.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

3644375..3648822

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001026047.5 → NP_001021218.1 Putative potassium channel regulatory protein unc-93 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021218.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q23024, Q23025, Q58A93, Q7JN54, Q7JN55, Q93380

Conserved Domains (2) summary

cd06174
Location:250 → 673

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam07690
Location:250 → 643

MFS_1; Major Facilitator Superfamily
NM_001381807.1 → NP_001366876.1 Putative potassium channel regulatory protein unc-93 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

cd17406
Location:245 → 673

MFS_unc93A_like; Protein unc-93 homolog A and similar proteins of the Major Facilitator Superfamily of transporters