gsr-1 Glutathione reductase, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: gsr-1
Official Full Name: Glutathione reductase, mitochondrial
Primary source: WormBase:WBGene00008117
Locus tag: CELE_C46F11.2
See related: AllianceGenome:WB:WBGene00008117
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables glutathione-disulfide reductase (NADPH) activity. Involved in several processes, including cell redox homeostasis; ecdysis, collagen and cuticulin-based cuticle; and response to superoxide. Located in cytosol and mitochondrion. Is expressed in several structures, including Ea; Ep; Epr; excretory canal; and reproductive system. Human ortholog(s) of this gene implicated in cataract and macular degeneration. Orthologous to human GSR (glutathione-disulfide reductase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gsr-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 5

Sequence:: Chromosome: III; NC_003281.10 (3650907..3652958)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Blocking autophagy in gsr-1 worms expressing aggregation-prone proteins results in strong synthetic developmental phenotypes and lethality, supporting the physiological importance of glutathione reductase in the regulation of misfolded protein clearance.
Title: Loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation.
the embryonic lethality of gsr-1 worms is prevented by restoring GSR-1 activity in the cytoplasm but not in mitochondria. Given the fact that the thioredoxin redox systems are dispensable in C. elegans, our data support a prominent role of the glutathione reductase/glutathione pathway in maintaining redox homeostasis in the nematode
Title: Glutathione reductase gsr-1 is an essential gene required for Caenorhabditis elegans early embryonic development.
role of GSR-1 in stress tolerance and longevity
Title: The glutathione reductase GSR-1 determines stress tolerance and longevity in Caenorhabditis elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C46F11.3 (e-PCR)
- UniSTS:313889

C46F11.2 (e-PCR)
- UniSTS:307344

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables NADP binding	IEA Inferred from Electronic Annotation more info
enables flavin adenine dinucleotide binding	IBA Inferred from Biological aspect of Ancestor more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables glutathione-disulfide reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione-disulfide reductase (NADPH) activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione-disulfide reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell redox homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell redox homeostasis	IEA Inferred from Electronic Annotation more info
involved_in cell redox homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in cellular response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in ecdysis, collagen and cuticulin-based cuticle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutathione metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glutathione metabolic process	IEA Inferred from Electronic Annotation more info
involved_in response to superoxide	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Glutathione reductase, mitochondrial

NP_001021220.1

Confirmed by transcript evidence

NP_001379392.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

3650907..3652958

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001026049.7 → NP_001021220.1 Glutathione reductase, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021220.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q86DB5, Q93379

Conserved Domains (3) summary

PRK06116
Location:19 → 467

PRK06116; glutathione reductase; Validated

pfam00070
Location:184 → 261

Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase

pfam02852
Location:357 → 465

Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain
NM_001393311.1 → NP_001379392.1 Glutathione reductase, mitochondrial [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

cl39093
Location:5 → 453

Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase