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acy-3 adenylate cyclase [ Caenorhabditis elegans ]

Gene ID: 175489, updated on 2-Nov-2024

Summary

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Official Symbol
acy-3
Official Full Name
adenylate cyclase
Primary source
WormBase:WBGene00000070
Locus tag
CELE_C44F1.5
See related
AllianceGenome:WB:WBGene00000070
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable calcium- and calmodulin-responsive adenylate cyclase activity. Involved in negative regulation of protein kinase C signaling and regulation of establishment of cell polarity. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See acy-3 in Genome Data Viewer
Location:
chromosome: III
Exon count:
13
Sequence:
Chromosome: III; NC_003281.10 (3774896..3786477, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene SAND domain-containing protein Neighboring gene Galectin Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Type 5 adenylyl cyclase disruption leads to enhanced exercise performance. Vatner DE, et al. Aging Cell, 2015 Dec. PMID 26424149, Free PMC Article
  2. EGL-4 promotes turning behavior of C. elegans males during mating. Rahmani S, et al. MicroPubl Biol, 2021. PMID 34423280, Free PMC Article
  3. The Dunce cAMP phosphodiesterase PDE-4 negatively regulates G alpha(s)-dependent and G alpha(s)-independent cAMP pools in the Caenorhabditis elegans synaptic signaling network. Charlie NK, et al. Genetics, 2006 May. PMID 16624912, Free PMC Article
  4. Systematic genetic interaction screens uncover cell polarity regulators and functional redundancy. Fievet BT, et al. Nat Cell Biol, 2013 Jan. PMID 23242217, Free PMC Article
  5. Heterotrimeric G proteins in C. elegans. Bastiani C, et al. WormBook, 2006 Oct 13. PMID 18050432, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium- and calmodulin-responsive adenylate cyclase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in cAMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cAMP-mediated signaling ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in cyclic nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein kinase C signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of establishment of cell polarity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
adenylate cyclase
NP_497765.4
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    3774896..3786477 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065364.7 → NP_497765.4  adenylate cyclase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EE33
    Conserved Domains (3) summary
    smart00044
    Location:696 → 873
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam07331
    Location:26 → 137
    TctB; Tripartite tricarboxylate transporter TctB family
    cl11967
    Location:221 → 382
    Nucleotidyl_cyc_III; Class III nucleotidyl cyclases
Nucleotide Protein
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