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amx-1 Lysine-specific histone demethylase 1B homolog [ Caenorhabditis elegans ]

Gene ID: 175493, updated on 2-Nov-2024

Summary

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Official Symbol
amx-1
Official Full Name
Lysine-specific histone demethylase 1B homolog
Primary source
WormBase:WBGene00000137
Locus tag
CELE_R13G10.2
See related
AllianceGenome:WB:WBGene00000137
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables FAD-dependent H3K4me/H3K4me3 demethylase activity. Predicted to be involved in epigenetic regulation of gene expression. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in chemosensory neurons. Orthologous to human KDM1B (lysine demethylase 1B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See amx-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
8
Sequence:
Chromosome: III; NC_003281.10 (3822403..3826260)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Chromosome condensation protein dpy-27 Neighboring gene ncRNA Neighboring gene Metal transporter cnnm-5 Neighboring gene Uncharacterized protein Neighboring gene pseudo Neighboring gene Cytochrome P450

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Histone Demethylase AMX-1 Regulates Fertility in a p53/CEP-1 Dependent Manner. Ren X, et al. Front Genet, 2022. PMID 35846143, Free PMC Article
  2. Histone demethylase AMX-1 is necessary for proper sensitivity to interstrand crosslink DNA damage. Zhang X, et al. PLoS Genet, 2021 Jul. PMID 34329293, Free PMC Article
  3. A C. elegans LSD1 demethylase contributes to germline immortality by reprogramming epigenetic memory. Katz DJ, et al. Cell, 2009 Apr 17. PMID 19379696, Free PMC Article
  4. C. elegans: a novel pharmacogenetic model to study Parkinson's disease. Nass R, et al. Parkinsonism Relat Disord, 2001 Jul. PMID 11331185
  5. SAMS-1 coordinates HLH-30/TFEB and PHA-4/FOXA activities through histone methylation to mediate dietary restriction-induced autophagy and longevity. Lim CY, et al. Autophagy, 2023 Jan. PMID 35503435, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Histone demethylase AMX-1 is necessary for proper sensitivity to interstrand crosslink DNA damage.
    Title: Histone demethylase AMX-1 is necessary for proper sensitivity to interstrand crosslink DNA damage.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables FAD-dependent H3K4me/H3K4me3 demethylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables FAD-dependent H3K4me/H3K4me3 demethylase activity IEA
Inferred from Electronic Annotation
more info
  
enables FAD-dependent H3K4me/H3K4me3 demethylase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in epigenetic regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Lysine-specific histone demethylase 1B homolog
NP_497772.2
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    3822403..3826260
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065371.7 → NP_497772.2  Lysine-specific histone demethylase 1B homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497772.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q21988
    Conserved Domains (3) summary
    pfam01593
    Location:361 → 813
    Amino_oxidase; Flavin containing amine oxidoreductase
    pfam04433
    Location:251 → 337
    SWIRM; SWIRM domain
    pfam13450
    Location:356 → 414
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q21988.3

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