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maph-1.3 Microtubule-associated protein futsch [ Caenorhabditis elegans ]

Gene ID: 175498, updated on 2-Nov-2024

Summary

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Official Symbol
maph-1.3
Official Full Name
Microtubule-associated protein futsch
Primary source
WormBase:WBGene00007966
Locus tag
CELE_C36A4.5
See related
AllianceGenome:WB:WBGene00007966
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable actin binding activity and microtubule binding activity. Predicted to be involved in microtubule cytoskeleton organization; neuron projection development; and regulation of microtubule depolymerization. Predicted to be part of microtubule associated complex. Predicted to be active in several cellular components, including dendrite; microtubule; and neuronal cell body. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness and periventricular nodular heterotopia. Orthologous to human MAP1A (microtubule associated protein 1A); MAP1B (microtubule associated protein 1B); and MAP1S (microtubule associated protein 1S). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See maph-1.3 in Genome Data Viewer
Location:
chromosome: III
Exon count:
7
Sequence:
Chromosome: III; NC_003281.10 (3844893..3848556)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene putative UDP-N-acetylglucosamine pyrophosphorylase Neighboring gene Cytochrome P450 Neighboring gene ncRNA Neighboring gene Breast cancer type 1 susceptibility protein homolog;RING-type E3 ubiquitin transferase BRCA1 Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. LAB-1 targets PP1 and restricts Aurora B kinase upon entrance into meiosis to promote sister chromatid cohesion. Tzur YB, et al. PLoS Biol, 2012. PMID 22927794, Free PMC Article
  2. Actin-dependent cytoplasmic streaming in C. elegans oogenesis. Wolke U, et al. Development, 2007 Jun. PMID 17507392
  3. The Caenorhabditis elegans RDE-10/RDE-11 complex regulates RNAi by promoting secondary siRNA amplification. Zhang C, et al. Curr Biol, 2012 May 22. PMID 22542102, Free PMC Article
  4. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article
  5. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dendrite development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
part_of microtubule associated complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Microtubule-associated protein futsch
NP_497778.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    3844893..3848556
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065377.3 → NP_497778.2  Microtubule-associated protein futsch [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497778.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18494
    Conserved Domains (1) summary
    PHA03247
    Location:217 → 551
    PHA03247; large tegument protein UL36; Provisional
Nucleotide Protein
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