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brc-1 Breast cancer type 1 susceptibility protein homolog;RING-type E3 ubiquitin transferase BRCA1 [ Caenorhabditis elegans ]

Gene ID: 175499, updated on 2-Nov-2024

Summary

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Official Symbol
brc-1
Official Full Name
Breast cancer type 1 susceptibility protein homolog;RING-type E3 ubiquitin transferase BRCA1
Primary source
WormBase:WBGene00000264
Locus tag
CELE_C36A4.8
See related
AllianceGenome:WB:WBGene00000264
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables ubiquitin protein ligase activity. Involved in several processes, including DNA repair; cellular response to ionizing radiation; and nuclear chromosome segregation. Part of BRCA1-BARD1 complex. Is expressed in germ line. Human ortholog(s) of this gene implicated in several diseases, including Fanconi anemia complementation group S; breast cancer (multiple); cervix uteri carcinoma in situ; gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human BRCA1 (BRCA1 DNA repair associated). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See brc-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
10
Sequence:
Chromosome: III; NC_003281.10 (3853102..3862968, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Microtubule-associated protein futsch Neighboring gene Cytochrome P450 Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene Acetyl-coenzyme A synthetase Neighboring gene Large ribosomal subunit protein uL3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DNA Strand Breaks in Mitotic Germ Cells of Caenorhabditis elegans Evaluated by Comet Assay. Park S, et al. Mol Cells, 2016 Mar. PMID 26903030, Free PMC Article
  2. In vivo analysis of FANCD2 recruitment at meiotic DNA breaks in Caenorhabditis elegans. Germoglio M, et al. Sci Rep, 2020 Jan 9. PMID 31919410, Free PMC Article
  3. BRCA1-mediated ubiquitylation. Boulton SJ. Cell Cycle, 2006 Jul. PMID 16861894
  4. One of these strains is not like the others: C. elegans DW102 has an altered dependence on brc-1 and brd-1 for regulation of cyp gene transcription. Thapa I, et al. MicroPubl Biol, 2024. PMID 38894809, Free PMC Article
  5. BRCA1 and BARD1 mediate apoptotic resistance but not longevity upon mitochondrial stress in Caenorhabditis elegans. Torgovnick A, et al. EMBO Rep, 2018 Dec. PMID 30366941, Free PMC Article

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Conservation of transcriptional regulation by BRCA1 and BARD1 in Caenorhabditis elegans.
    Title: Conservation of transcriptional regulation by BRCA1 and BARD1 in Caenorhabditis elegans.
  2. PARG and BRCA1-BARD1 cooperative function regulates DNA repair pathway choice during gametogenesis.
    Title: PARG and BRCA1-BARD1 cooperative function regulates DNA repair pathway choice during gametogenesis.
  3. Meiotic Double-Strand Break Processing and Crossover Patterning Are Regulated in a Sex-Specific Manner by BRCA1-BARD1 in Caenorhabditis elegans.
    Title: Meiotic Double-Strand Break Processing and Crossover Patterning Are Regulated in a Sex-Specific Manner by BRCA1-BARD1 in Caenorhabditis elegans.
  4. BRCA1-associated structural variations are a consequence of polymerase theta-mediated end-joining.
    Title: BRCA1-associated structural variations are a consequence of polymerase theta-mediated end-joining.
  5. the C. elegans homologs of the BRCA1/BARD1 tumor suppressor genes, brc-1/brd-1, were identified as mediators of the anti-apoptotic effect but dispensable for lifespan extension upon mitochondrial stress.
    Title: BRCA1 and BARD1 mediate apoptotic resistance but not longevity upon mitochondrial stress in Caenorhabditis elegans.
  6. Data suggest that BRC-1/BRD-1 can both promote and antagonize genome stability depending on whether homologous recombination is initiated during DNA double-strand break repair or during replication stalling.
    Title: Loss of Caenorhabditis elegans BRCA1 promotes genome stability during replication in smc-5 mutants.
  7. BRAP-2 is necessary for preventing an inappropriate response to elevated levels of reactive oxygen species by countering premature activation of BRC-1 and CKI-1.
    Title: Developmental arrest of Caenorhabditis elegans BRAP-2 mutant exposed to oxidative stress is dependent on BRC-1.
  8. brc-1 mutants show an abnormal increase in apoptosis and RAD-51 foci at pachytene that are abolished by loss of spo-11 function, suggesting a defect in meiosis rather than during premeiotic DNA replication.
    Title: BRC-1 acts in the inter-sister pathway of meiotic double-strand break repair.
  9. Ce-BRC-1 and Ce-BRD-1 share a role in C. elegans DNA repair processes.
    Title: BRCA1/BARD1 orthologs required for DNA repair in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA damage response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to ionizing radiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic chromosome separation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic sister chromatid segregation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nucleotide-excision repair IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nucleotide-excision repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of BRCA1-BARD1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Breast cancer type 1 susceptibility protein homolog;RING-type E3 ubiquitin transferase BRCA1
NP_001254882.1
  • Confirmed by transcript evidence
NP_001367205.1
  • Confirmed by transcript evidence
NP_001417850.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    3853102..3862968 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001430933.1 → NP_001417850.1  RING-type E3 ubiquitin transferase BRCA1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A679L8N4

  2. NM_001381810.2 → NP_001367205.1  Breast cancer type 1 susceptibility protein homolog [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B6VQ60, B6VQ61
    Conserved Domains (2) summary
    cl00038
    Location:505 → 598
    BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains
    cl17238
    Location:18 → 61
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  3. NM_001267953.3 → NP_001254882.1  Breast cancer type 1 susceptibility protein homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254882.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B6VQ60
    Conserved Domains (1) summary
    smart00292
    Location:13 → 95
    BRCT; breast cancer carboxy-terminal domain
Nucleotide Protein
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