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acs-19 Acetyl-coenzyme A synthetase [ Caenorhabditis elegans ]

Gene ID: 175500, updated on 2-Nov-2024

Summary

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Official Symbol
acs-19
Official Full Name
Acetyl-coenzyme A synthetase
Primary source
WormBase:WBGene00007969
Locus tag
CELE_C36A4.9
See related
AllianceGenome:WB:WBGene00007969
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable acetate-CoA ligase activity. Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process and regulation of response to oxidative stress. Is expressed in hypodermis; intestine; nervous system; and pharynx. Human ortholog(s) of this gene implicated in orofacial cleft. Orthologous to human ACSS2 (acyl-CoA synthetase short chain family member 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See acs-19 in Genome Data Viewer
Location:
chromosome: III
Exon count:
5
Sequence:
Chromosome: III; NC_003281.10 (3864489..3867098)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Cytochrome P450 Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene Breast cancer type 1 susceptibility protein homolog;RING-type E3 ubiquitin transferase BRCA1 Neighboring gene ncRNA Neighboring gene Large ribosomal subunit protein uL3 Neighboring gene ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase;NAD(+) hydrolase tir-1;Sterile alpha and TIR motif-containing protein 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Bacterial vitamin B(12) production enhances nematode predatory behavior. Akduman N, et al. ISME J, 2020 Jun. PMID 32152389, Free PMC Article
  2. NuRD mediates mitochondrial stress-induced longevity via chromatin remodeling in response to acetyl-CoA level. Zhu D, et al. Sci Adv, 2020 Jul. PMID 32789178, Free PMC Article
  3. A metabolic regulatory network for the Caenorhabditis elegans intestine. Bhattacharya S, et al. iScience, 2022 Aug 19. PMID 35847555, Free PMC Article
  4. Pathogenesis of human mitochondrial diseases is modulated by reduced activity of the ubiquitin/proteasome system. Segref A, et al. Cell Metab, 2014 Apr 1. PMID 24703696
  5. Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation. Oh SW, et al. Nat Genet, 2006 Feb. PMID 16380712

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables AMP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables CoA-ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables acetate-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables acid-thiol ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in acetyl-CoA biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in acetyl-CoA biosynthetic process from acetate IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
Acetyl-coenzyme A synthetase
NP_001021205.1
  • Confirmed by transcript evidence
NP_001021206.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    3864489..3867098
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001026035.4 → NP_001021206.1  Acetyl-coenzyme A synthetase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021206.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q65ZB8
    Conserved Domains (2) summary
    cd05966
    Location:34 → 655
    ACS; Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme)
    PRK00174
    Location:11 → 670
    PRK00174; acetyl-CoA synthetase; Provisional

  2. NM_001026034.6 → NP_001021205.1  Acetyl-coenzyme A synthetase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021205.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18496
    Conserved Domains (2) summary
    cd05966
    Location:44 → 665
    ACS; Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme)
    PRK00174
    Location:21 → 680
    PRK00174; acetyl-CoA synthetase; Provisional
Nucleotide Protein
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