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tir-1 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase;NAD(+) hydrolase tir-1;Sterile alpha and TIR motif-containing protein 1 [ Caenorhabditis elegans ]

Gene ID: 175502, updated on 2-Nov-2024

Summary

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Official Symbol
tir-1
Official Full Name
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase;NAD(+) hydrolase tir-1;Sterile alpha and TIR motif-containing protein 1
Primary source
WormBase:WBGene00006575
Locus tag
CELE_F13B10.1
See related
AllianceGenome:WB:WBGene00006575
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables several functions, including NAD+ nucleosidase activity; enzyme binding activity; and identical protein binding activity. Involved in several processes, including NAD catabolic process; defense response to other organism; and regulation of gene expression. Acts upstream of or within serotonin biosynthetic process. Located in axon cytoplasm and cell body. Is expressed in head; intestine; and pharynx. Used to study amyotrophic lateral sclerosis. Orthologous to human SARM1 (sterile alpha and TIR motif containing 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tir-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
14
Sequence:
Chromosome: III; NC_003281.10 (3869590..3901642, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Acetyl-coenzyme A synthetase Neighboring gene ncRNA Neighboring gene Large ribosomal subunit protein uL3 Neighboring gene putative methylmalonyl-CoA mutase, mitochondrial Neighboring gene Integrin beta pat-3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Immobilization of C. elegans with different concentrations of an anesthetic for time-lapse imaging of dynamic protein trafficking in neurons. Siete C, et al. MicroPubl Biol, 2024. PMID 38298463, Free PMC Article
  2. Olfaction regulates organismal proteostasis and longevity via microRNA-dependent signaling. Finger F, et al. Nat Metab, 2019 Mar. PMID 31535080, Free PMC Article
  3. Structure-function analysis of ceTIR-1/hSARM1 explains the lack of Wallerian axonal degeneration in C. elegans. Khazma T, et al. Cell Rep, 2023 Sep 26. PMID 37635352, Free PMC Article
  4. A phase transition enhances the catalytic activity of SARM1, an NAD(+) glycohydrolase involved in neurodegeneration. Loring HS, et al. Elife, 2021 Jun 29. PMID 34184985, Free PMC Article
  5. SARM1, an Enzyme Involved in Axon Degeneration, Catalyzes Multiple Activities through a Ternary Complex Mechanism. Icso JD, et al. Biochemistry, 2023 Jul 4. PMID 37307562, Free PMC Article

See all (100) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lysosome-related organelle integrity suppresses TIR-1 aggregation to restrain toxic propagation of p38 innate immunity.
    Title: Lysosome-related organelle integrity suppresses TIR-1 aggregation to restrain toxic propagation of p38 innate immunity.
  2. The defense response of Caenorhabditis elegans to Cutibacterium acnes SK137 via the TIR-1-p38 MAPK signaling pathway.
    Title: The defense response of Caenorhabditis elegans to Cutibacterium acnes SK137 via the TIR-1-p38 MAPK signaling pathway.
  3. A phase transition enhances the catalytic activity of SARM1, an NAD(+) glycohydrolase involved in neurodegeneration.
    Title: A phase transition enhances the catalytic activity of SARM1, an NAD(+) glycohydrolase involved in neurodegeneration.
  4. Thus, Bifidobacterium longum BB68 increased the longevity of nematodes by activating the TIR-1 - JNK-1 - DAF-16 signaling pathway, and the cell wall component of BB68 contributed to longevity.
    Title: The Transcription Factor DAF-16 is Essential for Increased Longevity in C. elegans Exposed to Bifidobacterium longum BB68.
  5. show that the expression of mutant proteins causative for ALS in Caenorhabditis elegans motor neurons induces an innate immune response via TIR-1/Sa
    Title: Neurodegeneration in C. elegans models of ALS requires TIR-1/Sarm1 immune pathway activation in neurons.
  6. The microRNA mir-71 inhibits calcium signaling by targeting the TIR-1/Sarm1 adaptor protein to control stochastic left/right neuronal asymmetry in C. elegans.
    Title: The microRNA mir-71 inhibits calcium signaling by targeting the TIR-1/Sarm1 adaptor protein to control stochastic L/R neuronal asymmetry in C. elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables NAD+ nucleosidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NAD+ nucleosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables signaling adaptor activity IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in NAD catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in NAD catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in antibacterial innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell-cell signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to fungus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of MyD88-independent toll-like receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to axon injury IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to axon injury IEA
Inferred from Electronic Annotation
more info
  
involved_in response to axon injury IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within serotonin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axon cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase;NAD(+) hydrolase tir-1;Sterile alpha and TIR motif-containing protein 1
NP_001021251.2
  • Confirmed by transcript evidence
NP_001299866.1
  • Confirmed by transcript evidence
NP_001299868.1
  • Confirmed by transcript evidence
NP_001367074.1
  • Confirmed by transcript evidence
NP_001368535.1
  • Confirmed by transcript evidence
NP_001370174.1
  • Partially confirmed by transcript evidence
NP_497784.1
  • Confirmed by transcript evidence
NP_497785.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    3869590..3901642 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065383.6 → NP_497784.1  NAD(+) hydrolase tir-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497784.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5I9W1
    Conserved Domains (4) summary
    cd09501
    Location:557 → 625
    SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
    cd09502
    Location:626 → 695
    SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
    smart00454
    Location:557 → 622
    SAM; Sterile alpha motif
    smart00255
    Location:707 → 850
    TIR; Toll - interleukin 1 - resistance

  2. NM_001026080.5 → NP_001021251.2  NAD(+) hydrolase tir-1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O17801, O17802, Q19373, Q7JMF4, Q7JMF5, Q86DA5
    UniProtKB/TrEMBL
    Q5I9W1
    Conserved Domains (3) summary
    cd09501
    Location:611 → 679
    SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
    cd09502
    Location:680 → 749
    SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
    smart00255
    Location:761 → 904
    TIR; Toll - interleukin 1 - resistance

  3. NM_001381812.1 → NP_001367074.1  NAD(+) hydrolase tir-1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5I9W1
    Conserved Domains (3) summary
    cd09501
    Location:428 → 496
    SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
    cd09502
    Location:497 → 566
    SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
    smart00255
    Location:578 → 721
    TIR; Toll - interleukin 1 - resistance

  4. NM_065384.7 → NP_497785.1  NAD(+) hydrolase tir-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497785.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5I9V9
    Conserved Domains (4) summary
    cd09501
    Location:216 → 284
    SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
    cd09502
    Location:285 → 354
    SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
    smart00454
    Location:216 → 281
    SAM; Sterile alpha motif
    smart00255
    Location:366 → 509
    TIR; Toll - interleukin 1 - resistance

  5. NM_001384059.3 → NP_001370174.1  NAD(+) hydrolase tir-1 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (3) summary
    cd09502
    Location:42 → 111
    SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
    smart00255
    Location:123 → 266
    TIR; Toll - interleukin 1 - resistance
    cl15755
    Location:1 → 41
    SAM_superfamily; SAM (Sterile alpha motif )

  6. NM_001381811.1 → NP_001368535.1  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AX54, Q5I9W1
    Conserved Domains (3) summary
    cd09501
    Location:557 → 625
    SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
    cd09502
    Location:626 → 695
    SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
    smart00255
    Location:707 → 850
    TIR; Toll - interleukin 1 - resistance

  7. NM_001312937.3 → NP_001299866.1  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5I9W0, Q5I9W1
    Conserved Domains (4) summary
    cd09501
    Location:611 → 679
    SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
    cd09502
    Location:680 → 749
    SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
    smart00454
    Location:611 → 676
    SAM; Sterile alpha motif
    smart00255
    Location:761 → 904
    TIR; Toll - interleukin 1 - resistance

  8. NM_001312939.3 → NP_001299868.1  Sterile alpha and TIR motif-containing protein 1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ART9
    Conserved Domains (4) summary
    cd09502
    Location:42 → 111
    SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
    smart00454
    Location:43 → 112
    SAM; Sterile alpha motif
    smart00255
    Location:123 → 266
    TIR; Toll - interleukin 1 - resistance
    cl15755
    Location:1 → 41
    SAM_superfamily; SAM (Sterile alpha motif )
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86DA5.2

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