msi-1 RNA-binding protein Musashi homolog 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: msi-1
Official Full Name: RNA-binding protein Musashi homolog 1
Primary source: WormBase:WBGene00003423
Locus tag: CELE_R10E9.1
See related: AllianceGenome:WB:WBGene00003423
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables mRNA binding activity. Involved in nervous system process. Located in cytoplasm. Is expressed in SMDVL; head neurons; and intestine. Orthologous to human MSI1 (musashi RNA binding protein 1) and MSI2 (musashi RNA binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See msi-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 8

Sequence:: Chromosome: III; NC_003281.10 (3964660..3976391, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study shows that the C. elegans neuronal musashi gene ortholog msi-1 regulates forgetting. Although MSI-1 is expressed in several neurons, memory length depends on the action of MSI-1 only in the AVA interneuron.
Title: Forgetting is regulated via Musashi-mediated translational control of the Arp2/3 complex.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R10E9.1 (e-PCR)
- UniSTS:320123

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in nervous system process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of translation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RNA-binding protein Musashi homolog 1

NP_001369851.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

3964660..3976391 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001384060.2 → NP_001369851.1 RNA-binding protein Musashi homolog 1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EFS2

Conserved Domains (2) summary

cd12323
Location:135 → 208

RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins

cd12576
Location:46 → 121

RRM1_MSI; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins