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unc-103 Cyclic nucleotide-binding domain-containing protein;Potassium voltage-gated channel unc-103 [ Caenorhabditis elegans ]

Gene ID: 175527, updated on 2-Nov-2024

Summary

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Official Symbol
unc-103
Official Full Name
Cyclic nucleotide-binding domain-containing protein;Potassium voltage-gated channel unc-103
Primary source
WormBase:WBGene00006830
Locus tag
CELE_C30D11.1
See related
AllianceGenome:WB:WBGene00006830
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable inward rectifier potassium channel activity. Involved in mating behavior and regulation of muscle contraction. Predicted to be located in membrane. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Is expressed in body wall musculature; neurons; non-striated muscle; and in male. Used to study long QT syndrome. Human ortholog(s) of this gene implicated in long QT syndrome; long QT syndrome 2; and short QT syndrome. Orthologous to several human genes including KCNH2 (potassium voltage-gated channel subfamily H member 2) and KCNH7 (potassium voltage-gated channel subfamily H member 7). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See unc-103 in Genome Data Viewer
Location:
chromosome: III
Exon count:
22
Sequence:
Chromosome: III; NC_003281.10 (4115385..4147278)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ABC transporter ATP-binding protein/permease wht-3;ABC transporter domain-containing protein Neighboring gene Hemiasterlin resistant protein 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A cholinergic-regulated circuit coordinates the maintenance and bi-stable states of a sensory-motor behavior during Caenorhabditis elegans male copulation. Liu Y, et al. PLoS Genet, 2011 Mar. PMID 21423722, Free PMC Article
  2. Postsynaptic ERG potassium channels limit muscle excitability to allow distinct egg-laying behavior states in Caenorhabditis elegans. Collins KM, et al. J Neurosci, 2013 Jan 9. PMID 23303953, Free PMC Article
  3. DNA topoisomerase 2-associated proteins PATL1 and PATL2 regulate the biogenesis of hERG K(+) channels. Yao L, et al. Proc Natl Acad Sci U S A, 2023 Jan 10. PMID 36608291, Free PMC Article
  4. Genetic screening in C. elegans identifies rho-GTPase activating protein 6 as novel HERG regulator. Potet F, et al. J Mol Cell Cardiol, 2009 Feb. PMID 19038263, Free PMC Article
  5. Behavioral genetics of caenorhabditis elegans unc-103-encoded erg-like K(+) channel. Reiner DJ, et al. J Neurogenet, 2006 Jan-Jun. PMID 16807195

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss-of-function mutations of cnx-1 decreased the protein level and current density of the UNC-103 K(+) channel and suppressed the behavioral defects caused by a gain-of-function mutation in unc-103 Moreover, CNX-1 facilitated tetrameric assembly of UNC-103 channel subunits in a liposome-assisted cell-free translation system.
    Title: A forward genetic screen identifies chaperone CNX-1 as a conserved biogenesis regulator of ERG K(+) channels.
  2. ER-located J-protein chaperones were identified as key regulators for the iogenesis and physiological function of ERG K+ channels. They regulate two distinct aspects of K+ channel biogenesis, the stabilization and assembly of channel subunits.
    Title: Tetrameric Assembly of K(+) Channels Requires ER-Located Chaperone Proteins.
  3. rho-GTPase activating protein 6 is novel regulator of HERG homolog UNC-103
    Title: Genetic screening in C. elegans identifies rho-GTPase activating protein 6 as novel HERG regulator.
  4. UNC-103 regulates contractile behaviors of sex muscles in males before and during mating.
    Title: Caenorhabditis elegans UNC-103 ERG-like potassium channel regulates contractile behaviors of sex muscles in males before and during mating.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables inward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mating behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of egg-laying behavior NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of muscle contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Cyclic nucleotide-binding domain-containing protein;Potassium voltage-gated channel unc-103
NP_001122687.1
  • Partially confirmed by transcript evidence
NP_001293649.1
  • Confirmed by transcript evidence
NP_001366693.1
  • Partially confirmed by transcript evidence
NP_001367165.1
  • Partially confirmed by transcript evidence
NP_001367166.1
  • Partially confirmed by transcript evidence
NP_001367167.1
  • Partially confirmed by transcript evidence
NP_001367168.1
  • Confirmed by transcript evidence
NP_001368173.1
  • Partially confirmed by transcript evidence
NP_001370238.1
  • Confirmed by transcript evidence
NP_001370239.1
  • Confirmed by transcript evidence
NP_001382275.1
  • Confirmed by transcript evidence
NP_001407487.1
  • Confirmed by transcript evidence
NP_001407488.1
  • Confirmed by transcript evidence
NP_001407489.1
  • Confirmed by transcript evidence
NP_001407490.1
  • Confirmed by transcript evidence
NP_001407491.1
  • Confirmed by transcript evidence
NP_001407492.1
  • Confirmed by transcript evidence
NP_001407493.1
  • Partially confirmed by transcript evidence
NP_001407494.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    4115385..4147278
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001306720.3 → NP_001293649.1  Potassium voltage-gated channel unc-103 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293649.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EFJ9
    Conserved Domains (4) summary
    COG0664
    Location:375 → 459
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:374 → 485
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:63 → 300
    Ion_trans; Ion transport protein
    pfam07885
    Location:243 → 297
    Ion_trans_2; Ion channel

  2. NM_001384063.2 → NP_001370238.1  Potassium voltage-gated channel unc-103 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5ECG3, G5EDE3, G5EE47, G5EFJ9, G5EFT6, G5EG15, G5EG91, G5EGQ1, M1Z8A0, M1ZJW5
    Conserved Domains (1) summary
    PLN03192
    Location:121 → 544
    PLN03192; Voltage-dependent potassium channel; Provisional

  3. NM_001420612.1 → NP_001407487.1  Cyclic nucleotide-binding domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8D7ZGA2

  4. NM_001395354.1 → NP_001382275.1  Cyclic nucleotide-binding domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8D7ZF36
    Conserved Domains (1) summary
    PLN03192
    Location:55 → 478
    PLN03192; Voltage-dependent potassium channel; Provisional

  5. NM_001420613.1 → NP_001407488.1  Cyclic nucleotide-binding domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8D7ZEP4

  6. NM_001420614.1 → NP_001407489.1  Cyclic nucleotide-binding domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8D7ZGL5

  7. NM_001381818.1 → NP_001367165.1  Potassium voltage-gated channel unc-103 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    PLN03192
    Location:113 → 536
    PLN03192; Voltage-dependent potassium channel; Provisional

  8. NM_001381819.1 → NP_001367166.1  Potassium voltage-gated channel unc-103 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    PLN03192
    Location:155 → 578
    PLN03192; Voltage-dependent potassium channel; Provisional

  9. NM_001381820.1 → NP_001368173.1  Potassium voltage-gated channel unc-103 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    PLN03192
    Location:190 → 613
    PLN03192; Voltage-dependent potassium channel; Provisional

  10. NM_001381821.1 → NP_001367167.1  Potassium voltage-gated channel unc-103 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    PLN03192
    Location:97 → 520
    PLN03192; Voltage-dependent potassium channel; Provisional

  11. NM_001420615.1 → NP_001407490.1  Cyclic nucleotide-binding domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8D7ZGB1

  12. NM_001381822.1 → NP_001367168.1  Potassium voltage-gated channel unc-103 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    PLN03192
    Location:93 → 516
    PLN03192; Voltage-dependent potassium channel; Provisional

  13. NM_001420616.1 → NP_001407491.1  Cyclic nucleotide-binding domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8D7ZEY3

  14. NM_001420617.1 → NP_001407492.1  Cyclic nucleotide-binding domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8D7ZEU0

  15. NM_001384064.1 → NP_001370239.1  Potassium voltage-gated channel unc-103 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    PLN03192
    Location:83 → 506
    PLN03192; Voltage-dependent potassium channel; Provisional

  16. NM_001381823.1 → NP_001366693.1  Potassium voltage-gated channel unc-103 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    PLN03192
    Location:83 → 506
    PLN03192; Voltage-dependent potassium channel; Provisional

  17. NM_001129215.1 → NP_001122687.1  Potassium voltage-gated channel unc-103 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122687.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EFJ9
    Conserved Domains (4) summary
    COG0664
    Location:421 → 505
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:420 → 531
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:109 → 346
    Ion_trans; Ion transport protein
    pfam07885
    Location:289 → 343
    Ion_trans_2; Ion channel

  18. NM_001420618.1 → NP_001407493.1  Cyclic nucleotide-binding domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8D7ZEX1

  19. NM_001420619.1 → NP_001407494.1  Cyclic nucleotide-binding domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8D8EJ82
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5EFJ9.1

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