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ceh-43 Homeobox domain-containing protein;Homeobox protein ceh-43 [ Caenorhabditis elegans ]

Gene ID: 175581, updated on 2-Nov-2024

Summary

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Official Symbol
ceh-43
Official Full Name
Homeobox domain-containing protein;Homeobox protein ceh-43
Primary source
WormBase:WBGene00000463
Locus tag
CELE_C28A5.4
See related
AllianceGenome:WB:WBGene00000463
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables DNA-binding transcription factor activity, RNA polymerase II-specific and cis-regulatory region sequence-specific DNA binding activity. Involved in dopaminergic neuron differentiation and embryo development. Predicted to be located in nucleus. Is expressed in several structures, including ABalaa; ABalap; anterior hypodermis; neurons; and somatic nervous system. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 4; orofacial cleft 15; split hand-foot malformation 1; split hand-foot malformation 1 with sensorineural hearing loss; and trichodontoosseous syndrome. Orthologous to several human genes including DLX1 (distal-less homeobox 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ceh-43 in Genome Data Viewer
Location:
chromosome: III
Exon count:
5
Sequence:
Chromosome: III; NC_003281.10 (4446638..4449943, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene REJ domain-containing protein Neighboring gene Annexin Neighboring gene ncRNA Neighboring gene tRNA-Arg Neighboring gene ncRNA Neighboring gene tRNA-Arg Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Caenorhabditis elegans distal-less ortholog ceh-43 is required for development of the anterior hypodermis. Aspöck G, et al. Dev Dyn, 2001 Nov. PMID 11747075
  2. Exon duplication from a fork head to a homeodomain protein. Bürglin TR, et al. Dev Genes Evol, 1999 Oct. PMID 10552305
  3. Contribution of the amino and carboxyl termini for PHA-4/FoxA function in Caenorhabditis elegans. Kaltenbach LS, et al. Dev Dyn, 2005 Oct. PMID 16127716
  4. Joint actions of diverse transcription factor families establish neuron-type identities and promote enhancer selectivity. Jimeno-Martín A, et al. Genome Res, 2022 Mar. PMID 35074859, Free PMC Article
  5. A combinatorial regulatory signature controls terminal differentiation of the dopaminergic nervous system in C. elegans. Doitsidou M, et al. Genes Dev, 2013 Jun 15. PMID 23788625, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cis-regulatory region sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion TAS
Traceable Author Statement
more info
 PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dopaminergic neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Homeobox domain-containing protein;Homeobox protein ceh-43
NP_001338832.1
  • Confirmed by transcript evidence
NP_497904.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    4446638..4449943 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065503.5 → NP_497904.1  Homeobox protein ceh-43 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497904.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q18273
    UniProtKB/TrEMBL
    Q95QC6
    Conserved Domains (1) summary
    pfam00046
    Location:105 → 158
    Homeobox; Homeobox domain

  2. NM_001351863.3 → NP_001338832.1  Homeobox domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1X7RBT1, Q95QC6
    Conserved Domains (1) summary
    pfam00046
    Location:105 → 168
    Homeobox; Homeobox domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q18273.1

Gene LinkOut

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