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ifet-1 Translational repressor ifet-1 [ Caenorhabditis elegans ]

Gene ID: 175583, updated on 2-Nov-2024

Summary

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Official Symbol
ifet-1
Official Full Name
Translational repressor ifet-1
Primary source
WormBase:WBGene00004132
Locus tag
CELE_F56F3.1
See related
AllianceGenome:WB:WBGene00004132
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable mRNA binding activity. Involved in negative regulation of translation. Located in P granule. Is expressed in gonad. Orthologous to human EIF4ENIF1 (eukaryotic translation initiation factor 4E nuclear import factor 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ifet-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
10
Sequence:
Chromosome: III; NC_003281.10 (4471411..4475150, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Ubiquitin-like domain-containing protein Neighboring gene tRNA-Arg Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Small ribosomal subunit protein eS1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ifet-1 is a broad-scale translational repressor required for normal P granule formation in C. elegans. Sengupta MS, et al. J Cell Sci, 2013 Feb 1. PMID 23264733, Free PMC Article
  2. Regulation of maternal Wnt mRNA translation in C. elegans embryos. Oldenbroek M, et al. Development, 2013 Nov. PMID 24131629, Free PMC Article
  3. zif-1 translational repression defines a second, mutually exclusive OMA function in germline transcriptional repression. Guven-Ozkan T, et al. Development, 2010 Oct. PMID 20826530, Free PMC Article
  4. An eIF4E-binding protein regulates katanin protein levels in C. elegans embryos. Li W, et al. J Cell Biol, 2009 Oct 5. PMID 19786575, Free PMC Article
  5. DAF-18/PTEN inhibits germline zygotic gene activation during primordial germ cell quiescence. Fry AL, et al. PLoS Genet, 2021 Jul. PMID 34288923, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. these findings suggest that IFET-1 is a key translational regulator and is required for normal P granule formation.
    Title: ifet-1 is a broad-scale translational repressor required for normal P granule formation in C. elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in P granule IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic ribonucleoprotein granule IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Translational repressor ifet-1
NP_001369844.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    4471411..4475150 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001384075.2 → NP_001369844.1  Translational repressor ifet-1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20898
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q20898.2

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