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wdr-48 WD repeat-containing protein 48 homolog [ Caenorhabditis elegans ]

Gene ID: 175600, updated on 2-Nov-2024

Summary

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Official Symbol
wdr-48
Official Full Name
WD repeat-containing protein 48 homolog
Primary source
WormBase:WBGene00009441
Locus tag
CELE_F35G12.4
See related
AllianceGenome:WB:WBGene00009441
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ubiquitin binding activity. Involved in positive regulation of locomotion involved in locomotory behavior; positive regulation of macromolecule metabolic process; and positive regulation of protein localization to cell surface. Is expressed in anal depressor muscle; head neurons; mu_int_L; mu_int_R; and tail. Orthologous to human WDR48 (WD repeat domain 48). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See wdr-48 in Genome Data Viewer
Location:
chromosome: III
Exon count:
14
Sequence:
Chromosome: III; NC_003281.10 (4578853..4581697)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Serine/threonine-protein kinase sel-5 Neighboring gene 26S proteasome non-ATPase regulatory subunit 5 Neighboring gene GUN4 domain-containing protein;Ras-associating domain-containing protein;SPK domain-containing protein Neighboring gene Divalent-cation tolerance protein CutA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The WD40-Repeat Protein WDR-20 and the Deubiquitinating Enzyme USP-46 Promote Cell Surface Levels of Glutamate Receptors. Hodul M, et al. J Neurosci, 2021 Apr 7. PMID 33622778, Free PMC Article
  2. The WD40-repeat proteins WDR-20 and WDR-48 bind and activate the deubiquitinating enzyme USP-46 to promote the abundance of the glutamate receptor GLR-1 in the ventral nerve cord of Caenorhabditis elegans. Dahlberg CL, et al. J Biol Chem, 2014 Feb 7. PMID 24356955, Free PMC Article
  3. The WD40-repeat protein WDR-48 promotes the stability of the deubiquitinating enzyme USP-46 by inhibiting its ubiquitination and degradation. Hodul M, et al. J Biol Chem, 2020 Aug 14. PMID 32587090, Free PMC Article
  4. A global analysis of genetic interactions in Caenorhabditis elegans. Byrne AB, et al. J Biol, 2007. PMID 17897480, Free PMC Article
  5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The WD40-repeat protein WDR-48 promotes the stability of the deubiquitinating enzyme USP-46 by inhibiting its ubiquitination and degradation.
    Title: The WD40-repeat protein WDR-48 promotes the stability of the deubiquitinating enzyme USP-46 by inhibiting its ubiquitination and degradation.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of locomotion involved in locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein deubiquitination IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in positive regulation of protein localization to cell surface IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
WD repeat-containing protein 48 homolog
NP_001129837.1
  • Confirmed by transcript evidence
NP_497930.2
  • Confirmed by transcript evidence
NP_497931.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    4578853..4581697
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065530.8 → NP_497931.2  WD repeat-containing protein 48 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497931.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20059
    Conserved Domains (4) summary
    COG2319
    Location:2 → 376
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:29 → 322
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam11816
    Location:530 → 678
    DUF3337; Domain of unknown function (DUF3337)
    sd00039
    Location:32 → 88
    7WD40; WD40 repeat [structural motif]

  2. NM_065529.9 → NP_497930.2  WD repeat-containing protein 48 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497930.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B3GWA7, Q20059, Q9U3G8
    Conserved Domains (4) summary
    COG2319
    Location:2 → 376
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:29 → 322
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam11816
    Location:530 → 681
    DUF3337; Domain of unknown function (DUF3337)
    sd00039
    Location:32 → 88
    7WD40; WD40 repeat [structural motif]

  3. NM_001136365.4 → NP_001129837.1  WD repeat-containing protein 48 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001129837.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20059
    Conserved Domains (4) summary
    COG2319
    Location:2 → 376
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:29 → 322
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam11816
    Location:530 → 695
    DUF3337; Domain of unknown function (DUF3337)
    sd00039
    Location:32 → 88
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q20059.2

Gene LinkOut

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