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ras-2 R-RAS related [ Caenorhabditis elegans ]

Gene ID: 175625, updated on 2-Nov-2024

Summary

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Official Symbol
ras-2
Official Full Name
R-RAS related
Primary source
WormBase:WBGene00004311
Locus tag
CELE_F17C8.4
See related
AllianceGenome:WB:WBGene00004311
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Noonan syndrome 11. Orthologous to human MRAS (muscle RAS oncogene homolog). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ras-2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
4
Sequence:
Chromosome: III; NC_003281.10 (4737592..4740075, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene F-box domain-containing protein Neighboring gene Aspartate dehydrogenase domain-containing protein Neighboring gene Major sperm protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An expanded GCaMP reporter toolkit for functional imaging in Caenorhabditis elegans. Ding J, et al. G3 (Bethesda), 2023 Sep 30. PMID 37565483, Free PMC Article
  2. Behavioral and immune responses to infection require Gαq- RhoA signaling in C. elegans. McMullan R, et al. PLoS Pathog, 2012 Feb. PMID 22359503, Free PMC Article
  3. Small GTPases. Lundquist EA. WormBook, 2006 Jan 17. PMID 18050472, Free PMC Article
  4. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
  5. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
R-RAS related
NP_497972.1
  • Product from WormBase gene class ras;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    4737592..4740075 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065571.7 → NP_497972.1  R-RAS related [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497972.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EGA7
    Conserved Domains (2) summary
    cd04145
    Location:16 → 180
    M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3
    smart00010
    Location:16 → 180
    small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
Nucleotide Protein
Heading Accession and Version

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