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mel-28 [ Caenorhabditis elegans ]

Gene ID: 175634, updated on 22-Aug-2024

Summary

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Official Symbol
mel-28
Primary source
WormBase:WBGene00003210
Locus tag
CELE_C38D4.3
See related
AllianceGenome:WB:WBGene00003210
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables molecular adaptor activity. Involved in mitotic sister chromatid segregation and nuclear pore complex assembly. Located in kinetochore; nuclear envelope; and nucleoplasm. Part of nuclear pore. Orthologous to human AHCTF1 (AT-hook containing transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: III
Exon count:
18
Sequence:
Chromosome: III; NC_003281.10 (4786080..4792391)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene WRKY transcription factor 14 Neighboring gene ENhancer of Uncoordination Neighboring gene HTH OST-type domain-containing protein Neighboring gene Rho-GAP domain-containing protein;WW domain-containing protein tag-325

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The nucleoporin MEL-28/ELYS: A PP1 scaffold during M-phase exit. Hattersley N, et al. Cell Cycle, 2017 Mar 19. PMID 28102742, Free PMC Article
  2. Identification of Conserved MEL-28/ELYS Domains with Essential Roles in Nuclear Assembly and Chromosome Segregation. Gómez-Saldivar G, et al. PLoS Genet, 2016 Jun. PMID 27341616, Free PMC Article
  3. Uncovering buffered pleiotropy: a genome-scale screen for mel-28 genetic interactors in Caenorhabditis elegans. Fernandez AG, et al. G3 (Bethesda), 2014 Jan 10. PMID 24281427, Free PMC Article
  4. A Nucleoporin at the Meiotic Kinetochore. Bonner AM, et al. Dev Cell, 2016 Sep 12. PMID 27623378
  5. MEL-28/ELYS is required for the recruitment of nucleoporins to chromatin and postmitotic nuclear pore complex assembly. Franz C, et al. EMBO Rep, 2007 Feb. PMID 17235358, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. During nuclear assembly, MEL-28 recruits PP1c to the periphery of decondensed chromatin, where it directs formation of a functional nuclear compartment. Thus, a pool of phosphatase activity associated with a kinetochore-localized nucleoporin contributes to two key events that occur during M-phase exit in metazoans: kinetochore disassembly and nuclear reassembly.
    Title: A Nucleoporin Docks Protein Phosphatase 1 to Direct Meiotic Chromosome Segregation and Nuclear Assembly.
  2. the cell can exit the division without reforming the nuclear envelope to uncover an intriguing role of the nucleoporin MEL-28 in mediating chromosome segregation via its interaction with PP1 at the kinetochore
    Title: A Nucleoporin at the Meiotic Kinetochore.
  3. MEL-28/ELYS is required for the recruitment of nucleoporins to chromatin and acts as a seeding point for postmitotic nuclear pore complex assembly.
    Title: MEL-28/ELYS is required for the recruitment of nucleoporins to chromatin and postmitotic nuclear pore complex assembly.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic sister chromatid segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear pore complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear envelope IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear inner membrane IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear pore IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear pore IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear pore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Protein mel-28
NP_497987.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    4786080..4792391
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065586.7 → NP_497987.2  Protein mel-28 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497987.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q18508
    Conserved Domains (3) summary
    cl26761
    Location:1112 → 1440
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    cl28033
    Location:1578 → 1776
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    cl28453
    Location:1040 → 1178
    PLN02341; pfkB-type carbohydrate kinase family protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q18508.2

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