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rars-1 arginine--tRNA ligase;putative arginine--tRNA ligase, cytoplasmic [ Caenorhabditis elegans ]

Gene ID: 175659, updated on 2-Nov-2024

Summary

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Official Symbol
rars-1
Official Full Name
arginine--tRNA ligase;putative arginine--tRNA ligase, cytoplasmic
Primary source
WormBase:WBGene00004679
Locus tag
CELE_F26F4.10
See related
AllianceGenome:WB:WBGene00004679
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable arginine-tRNA ligase activity. Involved in determination of adult lifespan; regulation of gene expression; and translation. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 9. Orthologous to human RARS1 (arginyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rars-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
10
Sequence:
Chromosome: III; NC_003281.10 (4914096..4917117, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Rhomboid-related protein 1 Neighboring gene ANK_REP_REGION domain-containing protein Neighboring gene DUF3149 domain-containing protein;Glutaredoxin domain-containing protein Neighboring gene PDZ domain-containing protein Neighboring gene Conserved Edge Expressed protein Neighboring gene putative DNA-directed RNA polymerases I, II, and III subunit RPABC3 Neighboring gene NEDD8-activating enzyme E1 regulatory subunit

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Role of oxygen consumption in hypoxia protection by translation factor depletion. Scott B, et al. J Exp Biol, 2013 Jun 15. PMID 23531825, Free PMC Article
  2. Delayed innocent bystander cell death following hypoxia in Caenorhabditis elegans. Sun CL, et al. Cell Death Differ, 2014 Apr. PMID 24317200, Free PMC Article
  3. Mitochondrial Proteostatic Collapse Leads to Hypoxic Injury. Kaufman DM, et al. Curr Biol, 2015 Aug 17. PMID 26234215, Free PMC Article
  4. Survival from hypoxia in C. elegans by inactivation of aminoacyl-tRNA synthetases. Anderson LL, et al. Science, 2009 Jan 30. PMID 19179530, Free PMC Article
  5. The general control nonderepressible-2 kinase mediates stress response and longevity induced by target of rapamycin inactivation in Caenorhabditis elegans. Rousakis A, et al. Aging Cell, 2013 Oct. PMID 23692540, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables arginine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arginine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in arginyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in arginyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
arginine--tRNA ligase;putative arginine--tRNA ligase, cytoplasmic
NP_001022551.1
  • Confirmed by transcript evidence
NP_001022552.1
  • Confirmed by transcript evidence
NP_001379725.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    4914096..4917117 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027380.8 → NP_001022551.1  putative arginine--tRNA ligase, cytoplasmic [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022551.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q19825
    Conserved Domains (4) summary
    cd00671
    Location:245 → 511
    ArgRS_core; catalytic core domain of arginyl-tRNA synthetases
    smart01016
    Location:132 → 219
    Arg_tRNA_synt_N; Arginyl tRNA synthetase N terminal dom
    PLN02286
    Location:133 → 713
    PLN02286; arginine-tRNA ligase
    cl12020
    Location:550 → 713
    Anticodon_Ia_like; Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains

  2. NM_001027381.6 → NP_001022552.1  arginine--tRNA ligase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022552.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q65ZK0
    Conserved Domains (4) summary
    cd00671
    Location:245 → 511
    ArgRS_core; catalytic core domain of arginyl-tRNA synthetases
    smart01016
    Location:132 → 219
    Arg_tRNA_synt_N; Arginyl tRNA synthetase N terminal dom
    PLN02286
    Location:133 → 677
    PLN02286; arginine-tRNA ligase
    cl12020
    Location:550 → 672
    Anticodon_Ia_like; Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains

  3. NM_001393333.1 → NP_001379725.1  putative arginine--tRNA ligase, cytoplasmic [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A5HU89
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q19825.2

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