C27F2.4 Methyltransferase BUD23 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: C27F2.4
Official Full Name: Methyltransferase BUD23
Primary source: WormBase:WBGene00016166
Locus tag: CELE_C27F2.4
See related: AllianceGenome:WB:WBGene00016166
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable rRNA (guanine) methyltransferase activity. Predicted to be involved in rRNA (guanine-N7)-methylation. Predicted to be located in cytoplasm and nucleus. Predicted to be active in nucleolus. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome. Orthologous to human BUD23 (BUD23 rRNA methyltransferase and ribosome maturation factor). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See C27F2.4 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 6

Sequence:: Chromosome: III; NC_003281.10 (4958321..4960304, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C27F2.4 (e-PCR)
- UniSTS:313758

C27F2.5 (e-PCR)
- UniSTS:309165

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables S-adenosylmethionine-dependent methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables rRNA (guanine) methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables rRNA (guanine) methyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in rRNA (guanine-N7)-methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA (guanine-N7)-methylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Methyltransferase BUD23

NP_498051.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

4958321..4960304 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065650.5 → NP_498051.1 Methyltransferase BUD23 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498051.1

Status: REVIEWED

UniProtKB/TrEMBL

Q18257

Conserved Domains (3) summary

COG0500
Location:23 → 253

SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]

pfam08241
Location:58 → 163

Methyltransf_11; Methyltransferase domain

pfam12589
Location:206 → 281

WBS_methylT; Methyltransferase involved in Williams-Beuren syndrome