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vps-22 Vacuolar-sorting protein SNF8 [ Caenorhabditis elegans ]

Gene ID: 175672, updated on 2-Nov-2024

Summary

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Official Symbol
vps-22
Official Full Name
Vacuolar-sorting protein SNF8
Primary source
WormBase:WBGene00016167
Locus tag
CELE_C27F2.5
See related
AllianceGenome:WB:WBGene00016167
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Predicted to be part of ESCRT II complex. Is expressed in body wall musculature; intestine; neurons; pharynx; and vulval muscle. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy. Orthologous to human SNF8 (SNF8 subunit of ESCRT-II). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See vps-22 in Genome Data Viewer
Location:
chromosome: III
Exon count:
7
Sequence:
Chromosome: III; NC_003281.10 (4960390..4961715, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Protein kinase domain-containing protein Neighboring gene Methyltransferase BUD23 Neighboring gene JmjC domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. VPS-22/SNF8 regulates longevity via modulating the activity of DAF-16 in C. elegans. Han S, et al. Biochem Biophys Res Commun, 2020 Oct 29. PMID 32829877
  2. The ESCRT-II proteins are involved in shaping the sarcoplasmic reticulum in C. elegans. Lefebvre C, et al. J Cell Sci, 2016 Apr 1. PMID 26906413, Free PMC Article
  3. Association of the endosomal sorting complex ESCRT-II with the Vps20 subunit of ESCRT-III generates a curvature-sensitive complex capable of nucleating ESCRT-III filaments. Fyfe I, et al. J Biol Chem, 2011 Sep 30. PMID 21835927, Free PMC Article
  4. The VPS-20 subunit of the endosomal sorting complex ESCRT-III exhibits an open conformation in the absence of upstream activation. Schuh AL, et al. Biochem J, 2015 Mar 15. PMID 25588614, Free PMC Article
  5. CeVPS-27 is an endosomal protein required for the molting and the endocytic trafficking of the low-density lipoprotein receptor-related protein 1 in Caenorhabditis elegans. Roudier N, et al. Traffic, 2005 Aug. PMID 15998324

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in multivesicular body sorting pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of ESCRT II complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ESCRT II complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Vacuolar-sorting protein SNF8
NP_498052.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    4960390..4961715 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065651.8 → NP_498052.1  Vacuolar-sorting protein SNF8 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498052.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18258
    Conserved Domains (1) summary
    pfam04157
    Location:8 → 228
    EAP30; EAP30/Vps36 family
Nucleotide Protein
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