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wdr-60 WD Repeat protein [ Caenorhabditis elegans ]

Gene ID: 175676, updated on 2-Nov-2024

Summary

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Official Symbol
wdr-60
Official Full Name
WD Repeat protein
Primary source
WormBase:WBGene00016165
Locus tag
CELE_C27F2.1
See related
AllianceGenome:WB:WBGene00016165
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Predicted to be involved in intraciliary transport. Predicted to be part of cytoplasmic dynein complex. Predicted to be active in ciliary plasm. Human ortholog(s) of this gene implicated in short-rib thoracic dysplasia 8 with or without polydactyly. Orthologous to human DYNC2I1 (dynein 2 intermediate chain 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See wdr-60 in Genome Data Viewer
Location:
chromosome: III
Exon count:
16
Sequence:
Chromosome: III; NC_003281.10 (4987209..4991450)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene putative F-box protein C27F2.7 Neighboring gene PCI domain-containing protein 2 homolog Neighboring gene Transmembrane protein 131 homolog Neighboring gene Guanine nucleotide exchange protein smcr-8 Neighboring gene Coiled-coil domain-containing protein 25 Neighboring gene Transmembrane protein 144 homolog

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dynein intermediate chains DYCI-1 and WDR-60 have specific functions in Caenorhabditis elegans. Higashida M, et al. Genes Cells, 2023 Feb. PMID 36461782
  2. A gene-centered C. elegans protein-DNA interaction network provides a framework for functional predictions. Fuxman Bass JI, et al. Mol Syst Biol, 2016 Oct 24. PMID 27777270, Free PMC Article
  3. WDR60-mediated dynein-2 loading into cilia powers retrograde IFT and transition zone crossing. De-Castro ARG, et al. J Cell Biol, 2022 Jan 3. PMID 34739033, Free PMC Article
  4. Functional genomics of the cilium, a sensory organelle. Blacque OE, et al. Curr Biol, 2005 May 24. PMID 15916950
  5. The relationship between intraflagellar transport and upstream protein trafficking pathways and macrocyclic lactone resistance in Caenorhabditis elegans. Brinzer RA, et al. G3 (Bethesda), 2024 Mar 6. PMID 38227795, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dynein intermediate chains DYCI-1 and WDR-60 have specific functions in Caenorhabditis elegans.
    Title: Dynein intermediate chains DYCI-1 and WDR-60 have specific functions in Caenorhabditis elegans.
  2. WDR60-mediated dynein-2 loading into cilia powers retrograde IFT and transition zone crossing.
    Title: WDR60-mediated dynein-2 loading into cilia powers retrograde IFT and transition zone crossing.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables dynein heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein light chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intraciliary transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in ciliary plasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytoplasmic dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
WD Repeat protein
NP_001367569.1
  • Product from WormBase gene class wdr;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    4987209..4991450
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001381848.1 → NP_001367569.1  WD Repeat protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18263
Nucleotide Protein
Heading Accession and Version

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