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wip-1 WH2 domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 175681, updated on 2-Nov-2024

Summary

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Official Symbol
wip-1
Official Full Name
WH2 domain-containing protein
Primary source
WormBase:WBGene00020094
Locus tag
CELE_R144.4
See related
AllianceGenome:WB:WBGene00020094
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables cytoskeletal regulatory protein binding activity. Involved in embryonic body morphogenesis; regulation of cell migration; and regulation of protein stability. Is expressed in hypodermis. Orthologous to human WIPF1 (WAS/WASL interacting protein family member 1); WIPF2 (WAS/WASL interacting protein family member 2); and WIPF3 (WAS/WASL interacting protein family member 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See wip-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
8
Sequence:
Chromosome: III; NC_003281.10 (5018639..5021120)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene DUF5683 domain-containing protein Neighboring gene La-related protein 1 Neighboring gene ncRNA Neighboring gene Mediator of RNA polymerase II transcription subunit 11 Neighboring gene C2H2-type domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Caenorhabditis elegans WASP-interacting protein homologue WIP-1 is involved in morphogenesis through maintenance of WSP-1 protein levels. Sawa M, et al. Biochem Biophys Res Commun, 2006 Feb 10. PMID 16378591
  2. WIP-1 and DBN-1 promote scission of endocytic vesicles by bridging actin and Dynamin-1 in the C. elegans intestine. Shi X, et al. J Cell Sci, 2019 Jun 17. PMID 31118234
  3. Wip1 promotes RUNX2-dependent apoptosis in p53-negative tumors and protects normal tissues during treatment with anticancer agents. Goloudina AR, et al. Proc Natl Acad Sci U S A, 2012 Jan 10. PMID 22065775, Free PMC Article
  4. Collagen and actin network mediate antiviral immunity against Orsay virus in C. elegans intestinal cells. Zhou Y, et al. PLoS Pathog, 2024 Jan. PMID 38190406, Free PMC Article
  5. Synaptic polarity depends on phosphatidylinositol signaling regulated by myo-inositol monophosphatase in Caenorhabditis elegans. Kimata T, et al. Genetics, 2012 Jun. PMID 22446320, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. cortactin-binding domain of WIP-1 serves as the binding interface for DBN-1 (also known in other organisms as Abp1), another actin-binding protein
    Title: WIP-1 and DBN-1 promote scission of endocytic vesicles by bridging actin and Dynamin-1 in the C. elegans intestine.
  2. Wip1 phosphatase promotes apoptosis in p53-negative tumors and protects normal tissues during treatment with anticancer agents.
    Title: Wip1 promotes RUNX2-dependent apoptosis in p53-negative tumors and protects normal tissues during treatment with anticancer agents.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables cytoskeletal regulatory protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in embryonic body morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
WH2 domain-containing protein
NP_741122.2
  • Confirmed by transcript evidence
NP_741123.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    5018639..5021120
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171109.4 → NP_741122.2  WH2 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741122.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8WT46
    Conserved Domains (1) summary
    smart00246
    Location:28 → 45
    WH2; Wiskott Aldrich syndrome homology region 2

  2. NM_171863.4 → NP_741123.2  WH2 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741123.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KZ22
    Conserved Domains (1) summary
    smart00246
    Location:28 → 45
    WH2; Wiskott Aldrich syndrome homology region 2
Nucleotide Protein
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