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alh-1 Aldehyde dehydrogenase domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 175691, updated on 2-Nov-2024

Summary

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Official Symbol
alh-1
Official Full Name
Aldehyde dehydrogenase domain-containing protein
Primary source
WormBase:WBGene00000107
Locus tag
CELE_F54D8.3
See related
AllianceGenome:WB:WBGene00000107
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable aldehyde dehydrogenase (NAD+) activity. Is expressed in head mesodermal cell; intestine; nervous system; pharynx; and rectal gland cell. Used to study obesity. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; artery disease (multiple); diabetes mellitus (multiple); and liver disease (multiple). Orthologous to several human genes including ALDH1B1 (aldehyde dehydrogenase 1 family member B1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See alh-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
5
Sequence:
Chromosome: III; NC_003281.10 (5077764..5080661)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene putative tRNA-dihydrouridine synthase-like protein C45G9.2 Neighboring gene Uncharacterized protein Neighboring gene Inactive tau-tubulin kinase ttbk-6 Neighboring gene ncRNA Neighboring gene Cytochrome c oxidase subunit 6A, mitochondrial

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Conserved missense variant in ALDH1A3 ortholog impairs fecundity in C. elegans. Wong WR, et al. MicroPubl Biol, 2021 Jan 14. PMID 33474529, Free PMC Article
  2. Fat accumulation in Caenorhabditis elegans triggered by the electrophilic lipid peroxidation product 4-hydroxynonenal (4-HNE). Singh SP, et al. Aging (Albany NY), 2008 Dec 18. PMID 20157589, Free PMC Article
  3. Mass spectrometric proteome analysis suggests anaerobic shift in metabolism of Dauer larvae of Caenorhabditis elegans. Mádi A, et al. Biochim Biophys Acta, 2008 Nov. PMID 18620082
  4. iProteinDB: An Integrative Database of Drosophila Post-translational Modifications. Hu Y, et al. G3 (Bethesda), 2019 Jan 9. PMID 30397019, Free PMC Article
  5. Ethanol-response genes and their regulation analyzed by a microarray and comparative genomic approach in the nematode Caenorhabditis elegans. Kwon JY, et al. Genomics, 2004 Apr. PMID 15028283

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables aldehyde dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Aldehyde dehydrogenase domain-containing protein
NP_001379805.1
  • Confirmed by transcript evidence
NP_498081.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    5077764..5080661
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392085.1 → NP_001379805.1  Aldehyde dehydrogenase domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IG19
    Conserved Domains (1) summary
    cd07091
    Location:1 → 415
    ALDH_F1-2_Ald2-like; ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins

  2. NM_065680.8 → NP_498081.2  Aldehyde dehydrogenase domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498081.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q20780
    Conserved Domains (1) summary
    cd07141
    Location:24 → 504
    ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like
Nucleotide Protein
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